April 4, 2013

ADH1 to Methanol to Formaldehyde

Posted in ASPARTAME tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , at 10:57 pm by PCOSLady

PCOS Lady:
Diabetics and most people are having their ADH1 levels checked yearly… This post explains what the ADH1 actually is… This is scary and may scare you straight! I hope you think twice about smoking and eating or drinking anything with aspartame in it…
~ “YOU” are choosing the rate you will die… Be it fast or slow…
~ Knowing all this, ask; How much does your health care professional care about you?
ADH1 to Methanol to Formaldehyde
Table 5.2 is the key chart — ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21
Table 5.2 is the key chart — ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21
[ See also:,
2013.03.13 292,095 visits in a week ]
[ welcome to a scientific bouquet — some tasty dishes are presented twice… ]
A liter of diet drink gives the same methanol (wood alcohol) as the smoke from a pack of cigarettes, 60 mg — methanol has a half-life in the human bloodstream of 3 hours, showing that its elimination is slow, while it reaches every part of the body and the fetus every minute.
Methanol is actually less toxic than ethanol, except when it goes easily into cells that also happen to have high levels of free floating ADH1 enzyme, in 19 specific human tissues, including inner walls of blood vessels in the brain and eye, as well as in the rods and cones of the retina — the methanol is made quickly into free floating formaldehyde inside these cells, where it naturally wrecks havoc, interfering with all biochemistry, just as in its well known uses for embalming and sterilizing medical tools.
The resulting stew of formaldehyde modified proteins activates the inflammation process of the immune system, producing complex evolving pussy lesions — brain in Alzheimer’s and multiple sclerosis, inner walls of blood vessels in atherosclerosis, skin fibroblasts in lupus, pancreas in diabetes 2, retina in macular degeneration, joint fibroblasts in rheumatoid arthritis
Methylation of DNA and RNA leads to cell dysfunction and death, many later cancers, and birth defects, spina bifida, autism, preterm birth, Fetal Alcohol Sydrome.
Two key ATP enzymes are impaired in mitochrondria, shutting down aerobic energy metabolism, leading to reduced metabolism and anaerobic buildup of lactic acid, resulting in acidosis.
Table 5.2: Target Organs of Methanol Toxicity (Bad ADH1 Sites)
pages 60-1 “While Science Sleeps” textbook 2012 January, 236 pages,
Chapter 5 “The Silent Battle That Turns Methanol into Disease” —
The key chart that summarizes how ADH1 enzyme in high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases:
7 ADH1 references (listed below) for 16 tissue types (some tissues have several diseases) 218, 220, 221, 357, 503, 514, 563, 637, 638, 640;
18 target tissues for formaldehyde harm;
Over 20 specific modern novel “diseases of civilization”;
Each with huge growth in incidence in the last 35 years — 25 references;
U shaped curve (those who never drink ethanol get twice the harm for 6 of these diseases as those who drink once daily, since ethanol is a potent antidote that prevents ADH1 from making methanol into formaldehyde) — 8 references;
18 diseases from smoking cigarettes (a strong methanol source) — 24 references;
13 diseases from using aspartame — 22 references;
Monte didn’t have enough room on this 2-page figure to include the suite of 12 of the same symptoms and tissues from cases of often fatal chronic and acute methanol toxicity, page 133, with copious references.
This is a work in progress, highly incomplete, as this is an introductory update on the status of an breakthrough paradigm in toxicology, that presents multiple strong lines of evidence, allowing any intelligent layperson to come to their own decisions about methanol and resulting chronic formaldehyde toxicity diseases for specific high ADH1 sites, ranging from breast cancer to diabetes 2.
Table 5.2: target organs of methanol toxicity (bad ADH1 sites)
~ brain, vascular tissue, tau protein — Alzheimer’s myelin basic protein — multiple sclerosis
vascular lining — headache, seizures, glioblastoma cancer
~ eye, retina, ADH1 in rods and cones — macular degeneration
~ blood vessels, intima and media (inner walls), LDL low density lipoproteins — atherosclerosis
~ skin, fibroblasts — skin cancer, dermatitis, lupus (SLE systemic lupus erythematosus)
~ breast, epithelial (milk ducts) — adenocarcinoma
~ kidney, epithelial tubule — kidney cancer, poor function
~ bone, synovial fibroblast — rheumatoid arthritis
~ pancreas, islets of Langerhans — reduced insulin, diabetes 2
~ lung, fibroblasts — COPD chronic obstructive pulmonary disease, adenocarcinoma
Fetus, no ADH1 in placenta,
DNA methylation — terata (birth defects), autism
liver, lung, kidney harm — preterm delivery
Liver, highest ADH1 in body, many targets — hepatic cancer
“While Science Sleeps” textbook, 2012 January:
“Methanol travels easily to breast tissue and has been found in human milk. 219
The cells that produce milk within the breast, cells prone to develop
the most common of breast cancers, adenocarcinoma 358, contain high
levels of ADH1 enzyme, 358 allowing methanol’s conversion to
formaldehyde [ inside the cells as free floating acidic hydrated
formaldehyde, highly reactive on both sides of molecule ].
Mammary epithelial cells have no way to protect themselves from
formaldehyde 216 — no means to render it harmless.
They, unlike other breast tissue, contain no aldehyde dehydrogenase
enzyme (ADH 3) that could transform formaldehyde into the
non-carcinogenic formic acid. 216
Of particular interest are recent findings implicating ADH as playing
a pivotal role in the formation of breast cancer, documenting a
greater incidence of the disease in women with higher levels of ADH1
activity in their breasts. 357″
Labreche F, Goldberg M.
Exposure to Organic Solvents and Breast Cancer in Women: A Hypothesis.
American Journal of Industrial Medicine 1997;32:1-14.
Triano E, Slusher L, Atkins T, Beneski J, Gestl S.
Class I Alcohol Dehydrogenase Is Highly Expressed in Normal Human
Mammary Epithelium but not in Invasive Breast Cancer
: Implications for
Breast Carcinogenesis. Cancer Research Arch 2003;63:3092-100.
Crabb D, Matsumoto M, Chang D, You M.
Overview of the role of alcohol dehydrogenase and aldehyde
dehydrogenase and their variants in the genesis of alcohol-related
. Proceedings of the Nutrition Society 2004;63:49-63.
Coutelle C.
Risk Factors in Alcohol Associated Breast Cancer: Alcohol
Dehydrogenase Polymorphism and Estrogens
. International Journal of Oncology 2004;25:1127-32.
#6 diabetes 2 risk high for 2 cans aspartame diet drink weekly 14
years 66K women study
, Guy Fagherazzi et al AJCN 2013 Jan — methanol
(cigarettes, aspartame) formed into formaldehyde inside cells in
pancreas by ADH1 enzyme, WC Monte paradigm: Rich Murray 2013.02.13
The WC Monte January 2012 text is available at Amazon.com, “While
Science Sleeps”, low cost ebook, backed by his online archive of 745
free full text medical research references at WhileScienceSleeps.com ,
while two full chapters are free: Chapter 9, “Multiple Sclerosis” and
12, “Autism and Other Birth Defects.”
ADH1 is “unusually highly concentrated” in the million tiny “isles
of Langerhans” in the pancreas, where the beta cells make insulin —
cigarette use correlates with diabetes 2 risk, with a doubling of risk
for smoking over a pack daily.
[ page 172, “While Science Sleeps”, 2012 January, Prof. Woodrow C.
Monte, Food Science and Nutrition, Arizona State University, retired
2004 ]
WhileScienceSleeps.com includes free online archive of 745 full
text medical research references:
Bühler R., Pestalozzi D., Hess M., Von Wartburg JP.
Immunohistochemical localization of alcohol dehydrogenase in human
kidney, endocrine organs and brain
Pharmacol Biochem Behav. 1983;
18 Suppl 1:55-9 1983;18(Suppl 1):55-9.
Willi C., Bodenmann P., Ghali WA., Faris PD., Cornuz J.
Active smoking and the risk of type 2 diabetes: a systematic review
and meta-analysis
JAMA 2007;298(22):2654-64.
Wei M, Gibbons L, Mitchell T, Kampert J, Blair S.
Alcohol intake and incidence of type 2 diabetes in men.
Diabetes Care 2000;23(1):16-21. Ming Wei mwei@cooperinst.org ]
Many of these diseases, including diabetes 2, are twice as harmful for
those who never drink ethanol, compared to those who have just one
standard drink a day, due to the inhibition by ethanol of formation of
formaldehyde from methanol by ADH1.
Many people are protected by methanol in their blood from fermentation by bacteria in the GI tract.
High levels of ADH1:
~ liver, kidney, lung;
~ intima and media (inner walls) of blood vessels, notably base of brain and retina;
~ rods and cones in retina;
~ purkinje cells of vermis in cerebellum;
~ islets of Langerhans in pancreas;
~ fibroblasts in skin, bone marrow, synovial tissues in joints;
~ milk ducts of breast;
Men have several times more ADH1 in their GI tract than women, so less methanol gets into the blood to attack other tissues, so now four times as many women get multiple sclerosis as men.
Sources of methanol (wood alcohol):
~ smoke from cigarettes, wood, peat;
~ aspartame, and chewing gums;
~ some dark wines and liquors;
~ fresh tomatoes, black currants;
~ unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers (including home preserves and jugs of apple cider by farming families);
~ jams jellies marmalades;
~ smoked fermented spoiled foods;
~ some fresh coffees;
~ approved food additive dimethyl dicarbonate;
~ vehicle fuels;
Medical chemical mortuary facilities, home and industry solvents, factories for processed wood and paper products — formaldehyde heated to 150 deg C releases methanol…
Eng L. Localizations of Spacific Brain Antigens.
In: Boese A, editor. Search for the Cause of Multiple Sclerosis and other Chronic Diseases of the Central Nervous System.
Basel: Verlag Chemie; 1980. p. 15-460.
Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system:
1. internat. symposion of Hertie Foundation in Frankfurt/Main, September 1979 / ed. by A.
Boese. — Weinheim, Deerfield Beach (Florida), Basel: Verlag Chemie, 1980.
ISBN 3-527-25875-2
Dr. Alfred Boese
GemeinnOtzige Hertie-Stiftung
Lyoner StraBe 15
D-6000 Frankfurt 71
Mori O, Haseba T, Kameyama K, Shimizu H.
Histological distribution of class III alcohol dehydrogenase in human brain.
Brain Research 2000;852:186-90.
Allili-Hassani A, Martinez S, Peralba J., et al.
Alcohol dehydrogenase of human and rat blood vessels:
Role in ethanol metabolism.
FEBS Letters 1997;405:26-30.
Buehler R, Hess M, Wartburg J.
Immunohistochemical Localization of Human Liver Alcohol Dehydrogenase in Liver Tissue, Cultured Fibroblasts, and HeLa Cells.
American Association of Pathologists 1982;108(1):89-99.
Coutelle C.
Risk Factors in Alcohol Associated Breast Cancer:
Alcohol Dehydrogenase Polymorphism and Estrogens. International Journal of Oncology 2004;25:1127-32.
Coutelle C, Höhn B, Benesova M, Oneta CM, Quattrochi P, Roth HJ, Schmidt-Gayk H, Schneeweiss A, Bastert G, Seitz HK. Department of Medicine
and Laboratory of Alcohol Research, Liver Disease and Nutrition,
Salem Medical Centre, Heidelberg, Germany.
Estonius M, Svensson S, Höög J.
Alcohol dehydrogenase in human tissues:
localisation of transcripts coding for five classes of the enzyme.
FEBS Lett. 1996;397:338-42.
Kinne R, Bräuer R, Stuhlmüller B, Palombo-Kinne E, Burmeste GR.
Macrophages in rheumatoid arthritis.
Arthritis Res 2000;2(3):189-202.
[ no mention of ADH1 — the cause of RA is unknown… ]
chronic formaldehyde toxicity diseases


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