March 28, 2017

HEALTH “KEYS”

Posted in FYI, RESEARCH, WAKE UP FYI tagged , , , , , , , , , , , , , , , , , , , , , , at 5:43 pm by PCOSLady

FYI::  Demodex Mites cause Rosacea 1st then move to the eyes causing blindness in time…~  2% tee tree oil diluted with walnut oil or ? rubbed lightly on areas kills them…

~O~

I am proven on what I know health wise .. I do medical research .. Have saved a man’s life from his doctors 3x, kept him out of the looney bin 2x ..

Cancer::  Dissolved a 11cm stomach cyst, dissolved stage 4 lymph node in a lung and shrunk a 17cm ovary cyst to 5cm all in 3 months .. Did what cancer doctors and chemo couldn’t in prior 9 months!

Christie Mason
PCOS Lady
https://pcoslady.wordpress.com/
~O~
Pass this all on to enlighten, inform and save lives!
~O~
HEALTH  “KEYs”
Google:  
any symptom or diagnosis & root cause
~  You find 1 to all are connected!
~  Tackle the 1st 4 causes then the rest…

~

ROOT CAUSES ARE:

~  Iodine Deficiency

~  Yeast Overgrowth

~  Parasites

~  Mercury Poisoning
~
Root Causes Cause:
~  Mineral Deficiencies
~  Vitamin Deficiencies

~
Print out all the symptom lists for iodine deficiency, yeast overgrowth, bad parasites and mercury poisoning .. Check your symptoms off .. Do the remedy, spacing each out a month apart .. Then recheck symptoms off and redo remedy for symptoms left…
~

REMEDIES:

1)   Iodine .. Health food store buy natural iodine for $8 .. 2 drops on back of hand, time how long for it to soak in.. 3+ hours = severely deficient!  .. Do 3 drops daily for 30 days and retest…

~  Iodine controls your thyroid .. The thyroid controls your whole body!

FACT: 90% of US people are iodine deficient

~

2)  Yeast Overgrowth .. Health food store buy natural candida cleanse for $40 .. Go to symptoms, print out, check off yours .. Do cleanse recheck off symptoms still showing  repeat cleanse a month after .. Then do cleanse every 3 years!

~  http://candidamd.com/candida/symptoms.html

~  http://www.EverestMedicalLabs.com/locations/ ..  Test bacteria and fungi

~  FACT: Any type belly or “love” handles means you have a yeast overgrowth!

FACT: Any type belly or “love” handles means you have a yeast overgrowth!
FACT: 90% of the US people have a yeast overgrowth!
FACT: Up to 97% of all cancer patients have a yeast overgrowth!

~

3)  Parasites .. Health food store buy natural parasite cleanse for $40 .. Go to the Extensive Parasite symptoms list, print out, check off yours .. Do the cleanse recheck off symptoms still showing  repeat cleanse a month after .. Then do cleanse every 3 years! Life spans vary from a day to years!

FACT: 80~85% of the US people have bad parasites

~  www.ParasiteTesting.com .. Test all bad parasites known in the world!

~  https://pcoslady.wordpress.com/2012/03/24/parasite-symptoms-extensive/

~  http://www.EverestMedicalLabs.com/locations/ ..  Test bacteria and fungi

~

4)  Mercury Poisoning .. Health food store buy natural heavy metals cleanse for $40.. Go to the Mercury Poisoning symptoms list, print out, check off yours .. Do the cleanse recheck off symptoms still showing  repeat cleanse a month after .. Then do cleanse every 3 years! 

FACT: 40% of US people have mercury poisoning.. Thought to be higher

~  https://pcoslady.wordpress.com/2013/05/01/mercury-poisoning-symptoms-lists/

~  https://pcoslady.wordpress.com/2013/10/15/maries-story-mercury-poisoning/

*  Best to have your silver fillings and dental work removed!

~

If you need me to advocate for you, contact me…  My crusade is to save lives!

Christie

April 14, 2015

Newborn Horses Give Clues to Autism

Posted in RESEARCH tagged , , , , , , , , , , , , at 7:28 pm by PCOSLady

Newborn Horses Give Clues to Autism
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Skin-to-skin contact with the mother as well as swaddling in a light blanket for newborns are often standard procedures that relate to Madigan’s tactile pressure for horses. (Thinkstock photo)

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Link between horses and humans?
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Story by Pat Bailey, video and photos by Joe Proudman
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Just a few hours after its birth, the long-legged brown foal stands in its stall, appearing on first glance to be sound, sturdy and healthy. But something is very wrong with this newborn horse.
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The foal seems detached, stumbles towards people and doesn’t seem to recognize its mother or have any interest in nursing. It even tries to climb into the corner feeder.
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The bizarre symptoms are characteristic of a syndrome that has puzzled horse owners and veterinarians for a century. But recently, UC Davis researchers have discovered a surprising clue to the syndrome and intriguing similarities to childhood autism in humans.
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Resembles children with autism
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“The behavioral abnormalities in these foals seem to resemble some of the symptoms in children with autism,” said John Madigan, a UC Davis veterinary professor and an expert in equine neonatal health.
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“There are thousands of potential causes for autism, but the one thing that all autistic children have in common is that they are detached,” said Isaac Pessah, a professor of molecular biosciences at the UC Davis School of Veterinary Medicine and a faculty member of the UC Davis MIND Institute, who investigates environmental factors that may play a role in the development of autism in children.
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Pessah, Madigan and other researchers in veterinary and human medicine recently formed a joint research group and secured funding to investigate whether abnormal levels of neurosteroids — a group of chemicals that modulate perception — may play a role in both disorders.
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They hope their efforts will help prevent and treat the disorder in foals and advance the search for the causes of autism, which affects more than 3 million individuals in the United States.
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Watch the video and read more…
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I know male babies can not flush mercury like females can… Mercury is a cause of autism…
~ http://drlwilson.com/do%20hair%20analysis.htm … 80% accurate!
~ Organic acid test
~
Bad parasites mimic autism!
~ www.ParasiteTesting.com
~
http://ucdavis.edu/ucdavis-today/2015/february/03-foals.html

Clues to autism are explored by UC Davis equine veterinarians working with human medicine doctors after finding a treatment for neonatal foal disorder in…
ucdavis.edu

September 12, 2014

Newborn Horses Give Clues to Autism

Posted in RESEARCH tagged , , , , , , , , , , , at 4:15 pm by PCOSLady

Newborn horses give clues to autism
~
Skin-to-skin contact with the mother as well as swaddling in a light blanket for newborns are often standard procedures that relate to Madigan’s tactile pressure for horses. (Thinkstock photo)
Link between horses and humans?
~
Story by Pat Bailey, video and photos by Joe Proudman
~
Just a few hours after its birth, the long-legged brown foal stands in its stall, appearing on first glance to be sound, sturdy and healthy. But something is very wrong with this newborn horse.
~
The foal seems detached, stumbles towards people and doesn’t seem to recognize its mother or have any interest in nursing. It even tries to climb into the corner feeder.
~
The bizarre symptoms are characteristic of a syndrome that has puzzled horse owners and veterinarians for a century. But recently, UC Davis researchers have discovered a surprising clue to the syndrome and intriguing similarities to childhood autism in humans.
~
Resembles children with autism
~
“The behavioral abnormalities in these foals seem to resemble some of the symptoms in children with autism,” said John Madigan, a UC Davis veterinary professor and an expert in equine neonatal health.
~
“There are thousands of potential causes for autism, but the one thing that all autistic children have in common is that they are detached,” said Isaac Pessah, a professor of molecular biosciences at the UC Davis School of Veterinary Medicine and a faculty member of the UC Davis MIND Institute, who investigates environmental factors that may play a role in the development of autism in children.
~
Pessah, Madigan and other researchers in veterinary and human medicine recently formed a joint research group and secured funding to investigate whether abnormal levels of neurosteroids — a group of chemicals that modulate perception — may play a role in both disorders.
~
They hope their efforts will help prevent and treat the disorder in foals and advance the search for the causes of autism, which affects more than 3 million individuals in the United States.
~
Watch the video and read more…
~
I know male babies can not flush mercury like females can… Mercury is a cause of autism…
~ http://drlwilson.com/do%20hair%20analysis.htm … 80% accurate!
~ Organic acid test
~
Bad parasites mimic autism!
~ www.ParasiteTesting.com
~
http://ucdavis.edu/ucdavis-today/2015/february/03-foals.html

Clues to autism are explored by UC Davis equine veterinarians working with human medicine doctors after finding a treatment for neonatal foal disorder in…
ucdavis.edu

April 25, 2013

Your Core Being

Posted in FYI, MINERALS, NATURAL WELL BEING, RESEARCH tagged , , , , , , , , , , , , , , , , at 4:23 pm by PCOSLady

Your ‘CORE’ Being
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PCOS Lady:
This explains why you need your minerals checked periodically! It shows why holistic and natural path doctors and ways do work!
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Excellent videos to be watched and listened to by Neil Tyson at the link below… He is frank about the truths!
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http://www.huffingtonpost.com/2013/04/23/neil-degrasse-tyson-origins-atomic-elements-bodies_n_3117063.html?icid=maing-grid7|main5|dl27|sec1_lnk3%26pLid%3D303383
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Neil deGrasse Tyson Explains The Origins Of Atomic Elements In Our Bodies (VIDEO)
The paper is entitled “Synthesis of the Elements in Stars” but is sometimes referred to as the B2FH paper, after the authors’ initials.
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Your ‘CORE’ Being: by Astrophysicist Neil Tyson
What’s the human body made of? Ninety-nine percent consists of atoms of just six elements: oxygen, carbon, hydrogen, nitrogen, calcium, and phosphorus, with the remaining one percent consisting of trace elements like magnesium, sulfur, and iron.

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Article: The Huffington Post | By Melissa Cronin4/23/20
~
Follow:
Video, Astrophysics, Element Synthesis, Elements, Neil deGrasse Tyson, Periodic Table Of Elements, Stellar Nucleosynthesis, Where Did We Come From, Where Elements Come From, Science News
~
What’s the human body made of? Ninety-nine percent consists of atoms of just six elements: oxygen, carbon, hydrogen, nitrogen, calcium, and phosphorus, with the remaining one percent consisting of trace elements like magnesium, sulfur, and iron.
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But where did those elements come from? That question long presented a puzzle to scientists. At least it did until the publication of a now-obscure scientific paper in the middle of the twentieth century, as celebrated astrophysicist Neil deGrasse Tyson explains in a new video (above).
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“There was a seminal paper — one of the most important research papers ever published — that gave us the description of the origin of the elements,” Tyson says in the video.
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The paper is entitled “Synthesis of the Elements in Stars” but is sometimes referred to as the B2FH paper, after the authors’ initials
. It was published in Reviews of Modern Physics in 1957. Before its publication, the prevailing theory held that all elements were products of the Big Bang 15 billion years ago. But this theory accounted only for light elements like hydrogen and helium.
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So where did the heavy elements found in nature come from?
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The B2FH paper argued that all heavy elements were created within stars via nuclear fusion — a process known as stellar nucleosynthesis. As stars cool and “die,” they release the heavy elements into space. Ultimately, some of this material is incorporated into planets and even our bodies.
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If the paper was so important, why do so few nonscientists know about it? According to Tyson, it’s because the paper’s origins don’t fit conventional notions of scientific discovery.
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“There was no lone scientist burning the midnight oil making the eureka discovery,” Tyson says. “It was a little messier than that. But the consequences of it are profound.”

September 27, 2012

Insulin Sensitivity Gene Found – PTEN

Posted in CANCER, RESEARCH tagged , , , , , , , , , , , , , , , , , , , , at 6:56 pm by PCOSLady

Insulin Sensitivity Gene Found – PTEN
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PCOS Lady:
Look into having your PTEN gene level tested…
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http://www.nejm.org/doi/full/10.1056/NEJMoa1113966
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PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity
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Background
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Epidemiologic and genetic evidence links type 2 diabetes, obesity, and cancer. The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growth and metabolic signaling. Germline PTEN mutations cause a cancer-predisposition syndrome, providing an opportunity to study the effect of PTEN haploinsufficiency in humans.
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http://mypcos.info/1/scientists-find-insulin-sensitivity-gene-may-lead-to-new-diabetes-treatments/
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Scientists find insulin sensitivity gene, may lead to new diabetes treatments
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The PTEN gene encodes for an enzyme that is part of the insulin signalling pathway in the body. It is known to have a role in controlling the body’s metabolism, and to play a part in cell growth. The Oxford team was interested in learning more about this dual role.
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There is an inherited genetic condition called Cowden syndrome caused by faults in the PTEN gene. It is very rare and is thought to affect perhaps one in 200,000 people, with around 300 people with the condition in the UK. PTEN’s role in cell growth sees people with Cowden syndrome develop many benign polyps in their skin, mouth and bowel, and have a higher risk than the general population of developing breast cancer, thyroid cancer and womb cancer.
~
Please read her entire page on the PTEN gene… Easier to understand for you…
~
GOOGLE:
PTEN
Cowden Syndrome
thyroid cancer PTEN
breast cancer PTEN
womb cancer PTEN
insulin PTEN
insulin sensitivity
insulin sensitivity PTEN
Diabetes PTEN
Germline PTEN
type 2 diabetes PTEN
obesity PTEN
cancer PTEN

March 28, 2012

IBS – Segment Findings

Posted in IBS, RESEARCH tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , at 8:57 pm by PCOSLady

IBS – Segment Findings
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PCOS Lady: I found this researching PCOS and the lymphatic system…
* IBS is caused by parasites as well…
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IBS SYMPTOMS
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~ gas (often painful) ~ *parasites
~ bloating (indigestion) ~ *parasites
~ acid reflux ~ *parasites
~ burning mouth or throat ~ *parasites
~ mouth blisters, cramps
~ abdominal pain (especially after eating or drinking) ~ *parasites
~ constipation and/or diarrhea (or alternating) ~ *parasites
~ mucus in the stool ~ *parasites
~ liquid seepage from the rectum ~ *parasites
~ heartburn ~ *parasites
~
* 9 of 10 symptoms are caused by parasites!
~ Most doctors are not trained to diagnose, handle or treat parasite infections…
~ Quest Diagnostics and Lab Corp only check for the most common type(s) of parasites!
~ www.Parasitetesting.com checks for every parasite known in the world!
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Man-made chemicals: the hidden role of the lymphatic system in the genesis of polycystic ovary, fibrocystic breast disease, and breast cancer.(Quantum Medicine Update)
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IBS – Findings
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While it is well known that carcinogens fuel carcinogenesis, research is scanty on the mechanisms underlying why and how PIPs are stored in the lymphatic and breast tissue and fail to be properly detoxified and excreted by the majority of today’s detoxification protocols.
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In the October 1994 Townsend Letter, I stated: “The wellspring of the immunologic defense is the lymphatic system.” 33 In the 2001 issue, I started: “We have discovered that a high percentage of IBS sufferers have duodenitis, dysbiosis, stagnant lymph flow, and drainage in the deep lymph channels of the gut. …
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Read the full article at the site…
http://www.highbeam.com/doc/1G1-196581578.html
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New Breakthroughs in Treating Irritable Bowel Syndrome
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Townsend Letter June 1, 2001 by Yanick Jr., Paul
Irritable bowel syndrome (IBS) is estimated to affect 1520% of adults. Also known as leaky gut syndrome, some IBS sufferers have constipation (difficult or infrequent bowel movements); others have diarrhea (frequent loose stools, often with an urgent need to have bowel movements); and some people experience both.
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Although mainstream doctors call IBS a functional disorder, it is only because they are unable to detect any sign of disease when the colon is examined in isolation from other organs and systems of the body. IBS causes a great deal of pain, discomfort and distress, and may cause damage to the intestines and liver, and interfere with or even block nutrient uptake causing chronic malnutrition.
Read the whole article at site:
~
http://www.highbeam.com/doc/1G1-75178726.html
~ New Breakthroughs in Treating Irritable Bowel Syndrome.
~
http://articles.mercola.com/sites/articles/archive/2012/07/22/mold-and-other-chronic-diseases.aspx?e_cid=20120722_SNL_Art_1
~ ** Dr Mercola & Dr Richie Shoemaker, MD … Effective Strategies to Identify and Correct the Inflammation Caused by Mold Exposure… They cover mold, algae, spirochetes, etc… causing asthma, MS, Fibromyalgia and more that upset our metabolism, etc.. causing inflammation in us… Taking drugs does no good unless directed at the causes… The video explains it all! Well worth telling your doctors about!
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SITES
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Irritable Bowel Syndrome & Highly Sensitive … – The Captains Lady
http://www.thecaptainslady.com/irritablebowel.htm
~ The Captain’s Lady … Natural remedies for Highly Sensitive People experiencing Irritable Bowel Syndrome… Informative information for you on other topics…
~
GOOGLE
IBS
irritable bowel syndrome
functional disorder
leaky gut syndrome
chronic malnutrition
parasites in humans
IBS parasites

November 17, 2008

Nov ’08 Research: Treatments, Causes, Risks

Posted in RESEARCH tagged , , , , , , , , , , , at 12:41 am by PCOSLady

New Studies Examine Treatments, Causes and Risks for
Women with PCOS

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Toronto, Canada, June 21, 2000 – New research presented today on treatments, causes and risks
associated with Polycystic Ovary Syndrome(PCOS)
, a disease that effects between five and 10 percent of reproductive aged women, offers a glimmer of hope to the millions of women who suffer from the disease. The research was presented today in a panel at ENDO 2000, The Endocrine Society’s 82nd Annual Meeting, which is taking place in Toronto from June 21-24. The new studies examine several areas of PCOS, including a possible gene that triggers PCOS, new treatments for the disease, the relationship between diet and PCOS and the risk of heart disease in women with PCOS….
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http://www.emergen.com/pages/research/pcos.html
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Two of the studies that were presented examined new treatments for women with PCOS. One study found that women with PCOS who reduced their dietary fat might improve some of their reproductive parameters. Another study of adolescent girls with PCOS found that treatment with metformin, a medicine that decreases the body’s requirement for insulin, improves irregular or absent periods, a symptom of PCOS in young girls; lessens body hair and acne; and promotes weight loss…. “We have shown that metformin, which is typically a diabetes treatment, is effective in treating young women with PCOS,” said Dr. Ken Lee Jones, an endocrinologist at the University of California, San Diego who presented the research on metformin. “The new information that is presented today will help improve the quality of life for the women throughout the world who suffer from this disease.” … Dr. Walter Futterweit and Dr. Yaron Tomer,
endocrinologists at Mount Sinai Medical Center in New York, presented a study that found an association between a marker near the insulin receptor gene and PCOS. Previous research has found that PCOS is hereditary. The new research discovered evidence that the insulin receptor gene, or a nearby gene, may cause the tendency for women to inherit PCOS…. “This type of research will ultimately lead to better diagnosis and treatment for women with PCOS,” said Dr. Tomer….
~
Additionally, the research suggests that the inheritance of PCOS is caused by subtle changes in the insulin receptor gene, which may alter its function in the ovaries…. “We hope that these findings will enable us to better understand the mechanisms leading to PCOS,” said Dr. Futterweit…. Two of the other studies examined risk factors for women with PCOS, including insulin resistance and heart disease. One
study, which was presented by Dr. David Ehrmann, an endocrinologist at the University of Chicago, found that women with PCOS function near their maximum ability to secrete insulin in response to glucose. According to this new research, any further reductions in insulin sensitivity would be met with inadequate compensation in insulin secretion…. Dr. Rose Christian, a clinical research fellow
at the Mayo Clinic, reported on additional research that points to an increased risk of coronary heart disease for women with PCOS. Researchers found that coronary artery calcium, a marker for atherosclerosis, is more common and extensive in women with PCOS than in ovulatory women of similar age,
weight and risk factors…. “Our research showed that women with PCOS are as likely to develop coronary calcium as men of the same age,” said Dr. Christian. “Normally, coronary calcium and heart disease are three to four times more common in young men than in women of the same age.” … “PCOS is a common yet, silent disease that affects thousands of women,” said Dr. Lisa Fish, an endocrinologist at Park
Nicollett Medical Center in Minneapolis, Minnesota. “These studies provide new options to women with PCOS in treating their illness and also offer new information on risks that are associated with the it, such as heart disease. In addition, this research looks into the genes that may cause PCOS and its relationship to diabetes.” … Based in Bethesda, Maryland, The Endocrine Society consists of over 9,000 scientists and physicians in more than 80 countries. Founded in 1916, The Endocrine Society is the world’s oldest, largest, and most active organization devoted to research on hormones, and the clinical practice of endocrinology. Together, these physicians, scientists, educators, nurses, and students who
make up the organization’s membership, represent all basic, applied, and clinical interests in endocrinology. To learn more about The Endocrine Society, and thefield of endocrinology, visit our web site at www.endo-society.org…. New Directions in the Treatment of Polycystic Ovarian Syndrome by Ellen
Friedman Bender … Polycystic Ovarian Syndrome (PCOS) is a hormonal disorder affecting between 5 percent and 10 percent of women of reproductive age. Although many people correctly associate PCOS with impaired fertility
– chronic anovulation and hyperandrogenism (elevated male hormones) are two of its cardinal symptoms, it is more than an infertility disorder. Increasingly, PCOS is being recognized as a major women’s health problem because of the havoc it wreaks on the endocrine system. Many women with PCOS suffer from endocrine abnormalities including insulin resistance which affects the bodies ability to metabolize
sugar and fat….Significantly, according to a research study, premenopausal women who have the disorder are seven times more likely to suffer from adult onset diabetes than women without PCOS. In addition, over time, many women with PCOS develop elevated levels of cholesterol and triglycerides so that here is a greater risk of heart attack and stroke for women in their forties and fifties. Moreover, because of their irregular menstrual cycles, women with PCOS are at greater risk for endometrial cancer. Women with PCOS also frequently encounter self- esteem and body-image issues arising from other frequent symptoms of the disorder including hirsutism (excess facial and body hair),obesity, acne and male-pattern baldness… Traditionally, treatment for PCOS has focused on individual symptoms instead of the syndrome as a whole. Thus, a woman with PCOS who was trying to get pregnant might be given fertility drugs such as clomid
or pergonal. A woman in her twenties might be given oral contraceptives to regulate her menstrual cycle or provera to periodically shed the lining of her uterus. Another woman might be given spironolactone to inhibit hair growth. But recent research suggests that there may be lifestyle changes and medications that by attacking the insulin resistance, actually treat the syndrome as a whole…. At the very least,
some doctors recommend that their PCOS patients follow a carbohydrate-restricted diet and increase their exercise level. But the cutting edge research in PCOS is in the area of insulin sensitizing drugs. Recent studies have found that insulin sensitizing drugs given to type 2 diabetics, such as metformin, may also benefit women with PCOS. In one study, recently reported in the New England Journal of Medicine, an insulin sensitizing drug called INS-1 not only induced ovulation in 86% of the PCOS patients in the study,
it also reduced their triglyceride and blood pressure levels, lowering their risk for cardiovascular disease. At the moment, however, none of these insulin sensitizing agents are FDA approved for the treatment of PCOS and some of them have unpleasant side effects…. Ellen Friedman Bender co-chaired
the American Infertility Association’s recent conference on PCOS, “Understanding Polycystic Ovarian Syndrome: A Reproductive and Metabolic Disorder.” A version of this article appeared in the November 1999 issue of the Women’s O.W.N. of NYU Medical Center newsletter….
~
Treatment Options For PCOS
This information is provided for informational purposes only and is in no way meant to replace advice from a qualified medical professional…. Until recently, only the symptoms of PCOS – hirsutism, acne, infertility – could be treated. In the past few years, however, there has been a great deal of research pointing to excess production of insulin and resulting insulin resistance as the root of the problem….
Treatment With Insulin-Sensitizing Medications – The Newest Option A number of recent studies have shown
that treating women with PCOS with insulin-lowering medications such as metformin (also known as
Glucophage), Avandia (rosiglitazone) and Actos (pioglitazone), used to treat adult-onset diabetes,
can not only reduce the risks of heart disease and diabetes in women with PCOS by treating the underlying
problems with insulin production and usage, but also relieve many of the bothersome symptoms and even
make weight loss possible.1, 2
~
(Please note that these are not weight-loss drugs; women whose weight problems stemmed from insulin resistance may lose weight when the problem is corrected.)
~
These drugs do not lower blood sugar and so are generally safe even for those with hypoglycemia3, but there may be side effects. Metformin often causes diarrhea and/or nausea, especially for the first few weeks and when the dosage is increased. This is most problematic if it’s taken without food; these problems may be minimized by taking it halfway through a meal. A rare side effect is lactic acidosis, which may be fatal if not detected. Rezulin (troglitazone) was also used for this purpose until recently, but has been taken off the market after reports of liver abnormalities and even a handful of
deaths in some people who were taking it. Avandia and Actos are chemically related to Rezulin, but the effective dosages are far lower (4-8 mg/day of Avandia or 45 mg/day of Actos vs. 200-400 mg/day of Rezulin), making liver complications less likely. In clinical trials involving over 4500 patients, there have been no reports of Avandia-related liver toxicity or related problems4, 5; there have also been no reports of such complications from Actos4, 6 Even so, the FDA has recommended that patients who already have elevated liver enzyme levels be monitored regularly. Some people who take Avandia or Actos experience
a slight weight gain. (This hasn’t been my experience, though – I’ve actually lost several pounds in the last few months.) It is important to be aware that all of these medications are currently only approved by the FDA (in the US – I’m not entirely sure of their approval status in other countries) for the treatment of diabetes. There is a lot of convincing research showing that most if not all cases of PCOS can be improved by treating insulin resistance, and these drugs treat diabetes by treating insulin resistance. So, they’re likely to be helpful to many women with PCOS, and doctors are allowed to prescribe an approved drug for any purpose they wish, but some (especially those who aren’t up to date on the new research) may not be willing to do this. I’m working on writing up some information about d-chiro-inositol, the first medication being studied specifically to treat PCOS-related insulin resistance, but I want to do more research before I post anything here. In the meantime, check out Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome. This is an abstract of an article that appeared last year in the New England Journal of Medicine summarizing the findings of a study of this drug in women with PCOS….
~
Birth Control Pills
Birth control pills treat a few of the symptoms of PCOS. They usually bring on a period each month (though some women with PCOS do not have regular periods even while taking birth control pills) which is important for women who do not have regular cycles because lack of menstruation puts a woman at higher risk for endometrial cancer. Some women find that hair problems either lessen or stop getting worse while on the pill, particularly with Diane-35 or Dianette (which contains cyproterone acetate, an anti-androgen), which is available in some countries in Europe and also in Ausralia and New Zealand but has not been approved in the United States. Acne may improve as well. Weight gain is highly variable –
for some women weight gain may stabilize while on the pill; for others it may get worse. Changing brands may help if you find yourself gaining weight or having other unpleasant side effects. The triphasic birth control pills, such as Ortho Tri-Cyclen, may be problematic in that the estrogen dose they provide in the early part of the cycle may be too low to prevent women with PCOS from developing follicles, possibly resulting in a greater number of cysts on the ovaries.1 …
~
Treating Hirsutism
Hirsutism can an extremely difficult and emotional issue in a society where women are expected to be smooth and hairless. Shaving, plucking, waxing, electrolysis and laser hair removal treatments may work in many cases but can be, depending on the method, time-consuming, messy, painful and/or very
expensive. Spironolactone (brand name Aldactone), if taken over a period of time, will stop new hair growth in many women with hirsutism and may possibly decrease existing growth for some. In countries where Diane-35 has been approved, it may be prescribed help with hair problems….
~
Provera
Provera or other forms of synthetic progesterone are often prescribed to women experiencing amenhorrea
(lack of periods). It’s common for a Provera-induced period to be more heavy or painful than usual, but it’s important that something be done to cause regular menstruation because prolonged amenhorrea may
increase a woman’s risk for endometrial cancer. This doesn’t mean that if you haven’t had a period
for a very long time that you are destined to get cancer, but it does introduce a higher than usual risk. Some women have had success using progesterone cream as an alternative to Provera….
~
1. Kidson, Warren. Polycystic ovary syndrome: a new direction in treatment. MJA 1998; 169: 537-540.
2. Hopkinson, Zoe E. C. et al. Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology, BMJ 1998;317:329-332
3. Perloe, Mark. Polycystic Ovarian Syndrome: Treatment With Insulin-Lowering Medications.
4. Fonseca, Vivian A. Overcoming Insulin Resistance and Preventing Cardiovascular Disease in Diabetes: The Contributions of the Thiazolidinediones.
5. Avandia Shows Promising Results in Combination Therapy
6. Actos Approved By FDA For Type II Diabetes
~
April 28, 1999
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New Drug May Help Women With Infertility Syndrome An investigational drug that helps insulin to function more efficiently appears to combat infertility in women with polycystic ovary syndrome (PCOS), the most common cause of female infertility, according to a research team funded in part by the National Institute
of Child Health and Human Development (NICHD). The drug, D-chiro- inositol, occurs naturally in fruits and vegetables and appears to have no side effects in the comparatively small number of PCOS
patients who took part in this preliminary trial….
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The study, conducted by researchers at Virginia Commonwealth University (VCU) in Richmond, appears in the April 29 issue of The New England Journal of Medicine….
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“These early results show a lot of promise,” said Dr. Donna Vogel, Associate Chief for Clinical Research in NICHD’s Reproductive Sciences Branch and NICHD program officer for the study. “Dr. Nestler and his
colleagues have shown that a substance naturally produced by the body to assist in insulin action promotes ovulation in the majority of PCOS patients who take it.” …
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PCOS affects from 5 to 10 percent of American women of reproductive age (as many as 5 million in all), explained the study’s principal investigator, John E. Nestler, M.D., chairman of endocrinology at
VCU’s Medical College of Virginia. The ovaries of women with PCOS appear to be filled with numerous small cysts. The cyst-like appearance results from an accumulation of immature ovarian follicles, the bubble-like structures which, upon maturation, rupture and give rise to the egg cell….
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The features of PCOS may include failure to ovulate or menstruate, abnormally high levels of insulin, obesity, high blood pressure, hardening of the arteries, and high triglyceride levels. (Triglycerides are fatty substances used for energy storage, and high triglyceride levels may increase the risk for coronary artery disease.) PCOS patients also have high levels of the male hormone testosterone, which may cause them to grow excess facial or body hair….
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* “PCOS is not just a reproductive disorder; it’s a major health concern for women who are affected,” Dr. Nestler said. “This is a promising new drug because not only does it dramatically improve ovulation, it improves a woman’s overall health.” …
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Dr. Nestler added that, traditionally, physicians have been able to treat only the symptoms of PCOS, and not eliminate its cause. For example, antiandrogens were prescribed to block the action of testosterone and reduce excessive hair growth. Birth control pills were used to regulate the menstrual cycle, and when the women sought to have children, they were treated with fertility drugs–either alone or in combination with in vitro fertililzation….
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Roughly two years ago, however, Dr. Nestler and his colleagues were successful in reducing the PCOS symptoms of a group patients by treating them with the drug metformin, used to treat insulin resistance in patients with adult onset (type II) diabetes. (Insulin resistance is the failure of cells to respond to insulin properly). Metformin increases the body’s sensitivity to insulin and allows the body to use insulin more efficiently. Troglitazone, another insulin- sensitizing agent, has similar effects in PCOS patients. * …
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Although both drugs do restore ovulation, both have a number of side effects. Metformin, for example, may cause diarrhea, nausea, and loss of appetite, and Troglitazone may be toxic to the liver….
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The current findings strongly suggest that PCOS results from a failure to use insulin properly. Presumably, Dr. Nestler said, this failure causes insulin levels to rise. The high insulin levels, in turn, cause a variety of other effects, such as high blood pressure, hardening of the arteries, and high triglyceride levels. Insulin also appears to have an effect on the ovaries, causing them to produce high levels of testosterone and similar compounds, which halt egg maturation and interfere with the menstrual cycle….
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In the current study, the researchers followed 44 obese women with PCOS; half received D-chiro-inositol, and half received a placebo. Of the 22 women who received the study drug, 86 percent ovulated, compared with only 27 percent of the women in the placebo group. Women who received D-chiro-inositol also saw improvements in insulin, blood sugar, blood pressure, testosterone and triglyceride levels. No side
effects were reported….
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Dr. Nestler explained that the body uses D-chiro-inositol to manufacture the D-chiro-inositol mediator, which allows the cell toprocess glucose after insulin binds to the cell’s surface. According
to Dr. Nestler, the research offers insight into the possible cause of insulin resistance in women with PCOS, which previously had been unknown. A PCOS patient’s insulin resistance could be due, in part, to
a D-chiro-inositol deficiency….
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NICHD is currently funding a trial of D-chiro-inositol in a large number of patients to further ascertain its safety and effectiveness. The drug is also being tested in patients with type II diabetes.
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The study drug is manufactured by INSMED Pharmaceuticals, Inc., which develops products to detect and treat insulin resistance. The research is funded by an NIH Small Business Innovation Research Grant. These
grants are given to independently owned and operated U.S. companies that have fewer than 500 employees….
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Polycystic Ovarian Syndrome
New Thought on an Old Disease
Polycystic Ovarian Syndrome (PCOS) has been a subject of intense interest and research since it’s initial description by Drs. Stein and Levinthal in the 1930′s. However, it was not until the 1980′s that an
association between this syndrome and insulin resistance was discovered, and only in the last several years that the benefit of insulin sensitize therapy in treating this condition has become known. Hence, the recent flurry of articles appearing not only in scientific journals but also in the lay press….
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Why all the fuss? Probably because virtually everyone has a friend, relative or acquaintance who is affected with this disease. It is seen in 5-9% of reproductive age women, making it arguably the most common endocrine abnormality in this age group….
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In spite of decades of research and volumes of material written on PCOS, there is not a universally agreed upon definition. The reasons for this is that the condition is a syndrome rather than a single
specific disease intensity. In other words, there are many discreet abnormalities, which may cause women to develop this syndrome, and each has certain unique features. However, although most of the “classic” signs or symptoms of PCOS are present in little more than half of women with this disease, irregular cycles with absent of infrequent ovulation is a prerequisite for labeling a patient with this diagnosis. Hair growth, acne, obesity, and the various hormonal and biochemical abnormalities associated with this condition are usually absent in at least a third of patients diagnosed with this condition….
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Traditional therapies for Polycystic Ovarian Syndrome include bilateral ovarian wedge resection (now largely replaced by medical therapy or laparoscopic ovarian diathermy) contraception if patient does not wish to conceive, and clomiphene citrate if the patient is desirous of conception….
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For patients who desire cycle control or relief from acne or hirsutism, oral contraceptives are the first line of management. Clomiphene citrate, which is an antiestrogen, can induce ovulation in PCOS patients by altering the natural secretion of ovulation enhancing hormones. However, only 60-80% of women with Polycystic Ovarian Syndrome will achieve regular spontaneous ovulation with this drug, and only about half of that number will ultimately conceive. The reason for this discrepancy between ovulation and pregnancy rates is not fully understood….
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More recently, the role of insulin resistance in this condition has become better understood. In some individuals, insulin resistance is probably responsible for the development of PCOS. In others, it is
merely an association, linked either to obesity or genetic factors. There is a tremendous amount of research presently being conducted in this arena….
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Of most significance to our patients with this condition, the role of insulin sensitizer therapy has become well known. There are three such medicines in used today, the common names of which are Actos, Avandia, and Glucophage. These medications allow the cells to respond more normally to the body’s insulin secretion which leads to a decrease in insulin production by the pancreas. The resulting decline in insulin levels affect a number of other pathways, ultimately improving a woman’s overall hormone balance and helping her to achieve ovulation more readily. In some women, insulin sensitizer therapy alone will
allow women with PCOS to ovulate and conceive. In others, medicines such as clomiphene citrate are still necessary. However, we now can help such women to ovulate with lower doses of clomiphene, and some
women who could not previously ovulate even with high and prolonged doses of Clomiphene can now conceive without having to resort to expensive injectable medications. Therefore, the extreme usefulness of
these medications in the treatment of this condition have become recognized as the first major medical advance in many years….
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Not all women with PCOS have insulin resistance, and many who do have only a mild problem, which would probably not benefit from use of insulin sensitizer therapy. Often, these women may achieve similar or
better results using other methods such as weight loss and exercise. Adjunctive medications such as Tamoxifen or Decadron, or injectable menotropins may also be used with excellent results. Finally, ovarian
diathermy, in which the ovaries are treated with electrical energy during an outpatient laparoscopic procedure, produces excellent ovulation and pregnancy rates. It is beyond the scope of this article
to delineate the situations which would favor one treatment modality over another….
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We have also become increasingly aware that there are sufficient long-term complications of insulin resistance and polycystic ovarian syndrome. During pregnancy, these patients display a higher incidence
of gestational diabetes, a potentially serious condition for the mother and fetus. Further on down the road it appears that women with PCOS are at significantly increased risk for hypertension, Type II
diabetes, and cardiovascular disease. There is currently much interest and research in this area, but as yet little information on how these potential complications are best avoided….
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If you have or think you may have polycystic ovarian syndrome or insulin resistance, see your physician, or your infertility specialist for testing. Further details may be found on our web site, or through
national organizations such as Resolve or American Society for Reproductive Medicine…..
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Future Research
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The role of insulin sensitizers in the long-term treatment of PCOS is still relatively new and hotly debated. More research is being conducted to determine the safety and efficacy of these treatments
[3]….http://pbl.cc.gatech.edu/mindy/952

It has also been found that PCOS is highly genetic. By studying families where PCOS is seen in several women, studies will hopefully be able to identify the gene(s) contributing to this disease. Dr.
Andrea Dunaif, Chief of the Division of Endocrinology, Metabolism, and Molecular Medicine at Northwestern University Medical School and a member of the Advisory Board for the Polycystic Ovary Syndrome Association, is the Principal Investigator of an ongoing National Institutes of Health-funded study examining the genetics of PCOS. She is recruiting women with PCOS (diagnosed or undiagnosed) and their
family members to study the genetics of this syndrome….
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http://hsc.virginia.edu/medcntr/centers/crr/

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