November 15, 2012

Parasites and Pollution = Sick

Posted in PARASITES, WAKE UP FYI tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , at 8:51 pm by PCOSLady

Her natural cures and remedies, in many cases, eliminate the need for drugs and doctors.
This idealistic woman who had spent 30 years of her life doing private clinical research and treating patients found herself pitted against the deep, angry pockets of medical associations, pharmaceutical companies and government cronies…
… Who were all trying to silence her. (Read about this later in this post)
PCOS Lady:
This woman spent 30 years of her life to tell you the truths(s) on why you get sick and are sick! I feel everyone needs to know the factual truth(s)… I hope you gain a new knowledge on the medical industry and why certain things are not done, exposed, the red tape, the road blocks we encounter, etc…
~ I will keep adding to this post as i research her findings…
~ QUESTION your doctor(s)…
According to the U.S. Centers for Disease control nearly 100 MILLION Americans are infected with internal parasites like pinworms, whipworms, and tapeworms just to name a few… many of which are passed from their pets to their owners.
Are Parasites Making YOU Sick?
* Do you suffer with a list of mysterious aches, pains and illnesses?
* Does your doctor brush off your concerns… or doesn’t seem to have answers?
* Are you taking prescription drugs for a condition… but see little benefit?
* Are you frustrated that your doctor treats the PAIN… instead of playing detective to eliminate the ROOT CAUSE of your ongoing discomfort?
* Has your doctor ever ONCE discussed parasites or toxins with you?
Because here’s the thing:
Just because modern medicine has decided to IGNORE the problem of parasites and environmental toxins doesn’t mean they’re not invading our bodies and making us sick.
Your body has been trying to rid itself of parasites and pollutants your entire life!
You’ve even seen the signs:
Your body makes stones… mucous secretions… toxic dumpsites. It uses swelling… inflammation… cysts… tumours… mystery pain… headaches… diarrhea… constipation… poor digestion… weight gain… water retention… eczema… psoriasis… warts… acne… insomnia… extreme fatigue… PMS… bad breath… unusual body odour… cramps… stomach pains… joint pain… and the list goes on!
At first, when you’re younger, these symptoms are a nuisance. You might just feel a bit ‘off.’ Maybe your doctor has even told you these things are ‘normal’ and ‘of little concern.’
But as time progresses, and your body has more and more trouble fighting off the invaders, you begin to feel really sick.
Your list of seemingly unconnected symptoms begin to snowball. And your health issues start to get serious. Really serious.
What has your body been trying to tell you?

Look At Some Of Dr. Clark’s Other Parasite Discoveries:
* Those sick with colds are ALWAYS polluted with mycotoxins (the extremely toxic substances made by food molds)!
* Everyone with cancer has the human intestinal fluke in their liver – but no one else does!
* Everyone with diabetes has the pancreatic fluke of cattle in their pancreas – but few others do.
* Everyone with environmental illness tested positive for Fasciola (sheep liver fluke) in their liver!

* Everyone with asthma tested positive for Ascaris in their lungs!
… And the list goes on and on.

Recommended Cures For All These Types Of Chronic Pain & Illness:
~ Appendicitis
~ Arthritis
~ Asthma
~ Back Of Neck Pain
~ Breast Lumps
~ Breast Pain
~ Breast Sensitivity
~ Bronchitis
~ Central Abdominal Pain
~ Chest Pain
~ Chronic Cough
~ Colitis
~ Crohn’s Disease
~ Croup
~ Ear Noise / Ringing
~ Earaches
~ Elbow Pain
~ Endometriosis
~ Eye Pain
~ Fibromyositis
~ Fibromyalgia
~ Finger Pain
~ Foot Pan
~ Front Neck Pain
~ Groin Pain
~ Headaches
~ Heart Pain
~ Heel Pain
~ Hiatal Hernia
~ Hip Pain
~ Hot Flashes
~ Infertility
~ Inflammation
~ Interstitial Cystitis
~ Irritable Bowel Syndrome
~ Joint Pain
~ Leg Pain
~ Lower Abdominal Pain
~ Lower Back Pain
~ Macular Degeneration
~ Menopausal Symptoms
~ Mid-abdomen Pain
~ Nausea
~ Prostate Problems
~ Respiratory Illness
~ Scalp Pain
~ Shoulder Pain
~ Side Pain
~ Slow Pulse / Passing Out
~ Spastic Colon
~ Stomach Pain
~ Stomach Ulcer
~ Temporalmandibular Joint Problems (TMJ)
~ The Silent Cervix
~ Thigh Pain
~ Throat Pain
~ Thumb Pain & Hand Pain
~ Toe Pain
~ Tooth Ache
~ Upper Arm Pain
~ Upper Back Pain
~ Urinary Tract Pain
~ Uterine Pain
~ Wrist Pain
As Well As Recommended Cures For All Of These
Non-Painful Diseases:

~ Acne
~ Alcoholism
~ Alzheimer’s
~ Autism
~ Burning
~ Dementias
~ Depression
~ Diabetes
~ Diaper Rash
~ Digestion Problems
~ Eczema
~ Fatigue
~ Fever
~ Fluke Disease
~ Glaucoma
~ Herpes
~ High Blood Pressure
~ Hives
~ Insomnia
~ Manic Depression
~ Memory Loss
~ Multiple Sclerosis (MS)
~ Muscle Diseases
~ Muscular Dystrophy
~ Myasthenia Gravis
~ Numbness
~ Pre-Diabetes
~ Psoriasis
~ Schizophrenia
~ Sebaceous Cysts
~ Seizures
~ Skin Problems
~ Skin Rash
~ Sleep Apnea
~ Sleep Problems
~ Tapeworm Stages
~ The Flu
~ Tooth Decay
~ Universal Allergies
~ Warts
~ Weight Problems
~ Yeast Infections
Dr. Hulda Clark Uncovered A Startling Truth:
There Are Only 2 Real Health Problems:
That’s right, according to Dr. Clark, no matter how long and confusing your list of symptoms may be…
… From joint pain to chronic inflammation to irritable bowel syndrome or eczema…
Your issues of pain and illness can typically be traced back to 2 problems:
* Parasites and/or Pollution. *
And during her 30 years of clinical research and patient study, she concluded:
• If you can get rid of the parasites from your body…
• And if you can prevent them from re-invading by eliminating pollution and toxins from your environment…

… Then you can rid your body of disease and pain and restore health!
Sound crazy? Not convinced parasites could be at the root of your chronic pain issues?
I must tell you, I wasn’t a believer to start, either. Beyond discussions of hand washing to prevent colds and the spread of e-coli, when do we EVER talk about parasites?
(Outside of deworming our pets???)
But, in fact, Dr. Clark found that every person suffering with a ‘mysterious illness’ or ‘incurable pain’ was ALWAYS infected with some parasite or pollutant!
Including those suffering with joint pain, arthritis and inflammation!
In fact, she found that all her patients suffering with joint pain (in any form) were typically infected with as many as 4 specific types of worms!
And she found that exposure to three specific toxins as well as certain solvents in your home environment made you vulnerable to these parasites by lowering your body’s immunity and allowing the tiny larvae to infest and live within your muscles and joints…
… While opening the door for invasion by other parasites, bacteria and viruses, too!
How To Eliminate The Parasites. And — Eliminate
The Source Of The Parasites.

~ The 21-minute cure for killing parasites in your body.
~ How to kill the WORST parasite (found in the liver of every cancer patient)!
~ Why many family health problems are not ‘genetic’ – but a result of sharing the same house, dentist and lifestyle habits!
~ 100s of diet and household items that are common sources of parasites.
~ The MOST COMMON sources of arsenic, mercury, lead, cobalt, asbestos, and Freon in your home! (Yes, they’re still sneaking into your home today!)
~ How to kill 129 bacteria and viruses responsible for Lyme Disease, e-Coli, Pneumonia, Meningitis, Herpes, Salmonella, Skin Infections and more!
~ How to flush your body of 134 different kinds of round worms, flat worms, tape worms, mites and one-celled animals.
~ Household sources of heavy metals, lanthanides, PCBs and more.
~ The 23 toxins found in tooth fillings and how they’re threatening your health. PLUS – the conversation you need to have with your doctor.
~ The 7 most DEADLY, life-threatening solvents in your environment – and how to eliminate them.
~ The #1 source of asbestos in your home that almost NOBODY knows about! (You will be horrified, and then relieved you know what to do.)
~ Common sources of formaldehyde fumes in your home! (Stop risking lung problems; discover what to eliminate.)
~ Got a house with a yard? You’re likely exposing yourself to arsenic every spring and summer without even realizing it! Learn the source!
~ How to quickly cure the common cold. (Forget your mom’s home remedy; do this first!)
Why Bad Foods Taste Good.
And How To Make Diet Changes That Reduce Your
Exposure To Toxins & Parasites!

~ Do you experience frequent salt cravings? Are you often fatigued? It could be a sign that your adrenal glands could use some support. Use a cleanse.
~ Do you experience INTENSE cravings for breads, pasta, and potatoes? It could be a sign that your body is ‘craving’ these starches to help absorb and mop up toxins – or a parasitic infection!
~ Are you craving SUGAR? Try adding 1mg of THIS to your diet for 7 days. If you’re still craving sugar after a week, it could be a sign that pancreatic flukes are upsetting your sugar regulation. Get info on wiping out the infestation.
~ Also – for tips on curing cravings for pickles, bacon, sugar coated cereals, ice cream, caffeine, candy, pretzels and potato chips.
How To Clean Up Your Home To Prevent Reinfection
(Or First Time Infection!)
~ Cysts are the ‘eggs’ made by parasites and are SO TOUGH not even bleach will kill them. Discover the secret to preventing them from entering your mouth and hatching in your stomach. (HINT: Hand washing is important, but not enough.)
~ Why you can’t rely on bleach to sterilize laundry contaminated by the fecal matter and secretions on your underwear. But these 3 simple tricks should solve your problem.
~ Is your house full of mites? Find out – and then use Dr. Clark’s action plan to begin systematically getting them out of your home.
~ Are you suffering from chronic pain or illness? It’s a sign of a constant ‘source’ in your environment or diet that needs to be removed because your body is constantly fighting these pollutants. If you’re not getting better, it’s a sign you need to eliminate the source!
~ Are you suffering from joint pain, knee pain, foot pain or hip pain? Your dental work could be to blame.
~ The horrors of store-bought beverages – from milk to fruit juice to pop to bottled water to teas and coffee, you will be shocked at what you’ve been poisoning your body with!
~ The dangers lurking in your cosmetics cupboard.
~ Be a savvy consumer! Learn to read labels – and uncover the LIES that appear with clever wording even on so-called NATURAL cosmetic and body care products.
~ Protect yourself from the #1 source of Freon (CFCs) in your home.
~ 7 NATURAL body deodorants
~ Dr. Clark’s recipes for 17 natural skin care products and cosmetics.

~ 8 recipes for natural household cleaners.
Stop Being Held Hostage By Your Doctor
Dr. Clark said it best…
“Since the beginning of time, the sick have been held hostage by doctors and healers who surround themselves with mystery as they use herbs, chemicals and all manners of mysterious remedies to ‘cure’ and help the sick recover…
… And this mystery is used to justify the extraordinary costs of your diagnosis and healing.”

Dr. Clark was actually advised to patent her medical inventions.
She never did. Instead, she believed that her knowledge should be readily, freely available to whomever needed it.
She was on a mission to bring the world out of the dark ages of medicine and illness. And to learn the true causes of infection and disease.
She was keen to usher in a new age of disease-free living.
And so, to continue her legacy, I believe…
Wishing you abundant health & pain-free living,
Jesse Cannone
Co-Founder, The Healthy Back Institute®
Dr. Clark Was Falsely And Unjustly Accused,
In My Opinion, Of Being A ‘Quack’
Dr. Clark was harassed.
(Jailed at the age of 71, and held without bail for more than 2 weeks!)
And then finally driven out of the country into Mexico, where she fled and continued to practice against all odds.
Why? Well, you can probably guess…
Her natural cures and remedies, in many cases, eliminate the need for drugs and doctors.
So this idealistic woman who had spent 30 years of her life doing private clinical research and treating patients found herself pitted against the deep, angry pockets of medical associations, pharmaceutical companies and government cronies…
… Who were all trying to silence her.
It wasn’t a fair fight.
And even now that Dr. Clark is gone (she died in September 2009), there is STILL an insidious public relations machine that continues to pump out slanderous information, painting her as a quack and fraud of monstrous proportions.
Hulda Clark

May 1, 2012

ACNE: Hidradenitis Suppurativa (HS)

Posted in ACNE (mild to severe) tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , at 6:27 pm by PCOSLady


ACNE (severe)
Hidradenitis Suppurativa (HS)
HS effects both men and women it seems… I have experienced minor bouts of this through my life… Luckily they went away… Acne, we all experience it, PCOS women usually have it start on the face, then it moves to our shoulders, etc… We get the few on our breasts and groin areas… Some women try treating acne for years with little success… You may have HS… I suggest keeping this info on hand for your doctor…
~ This can be caused by “bad” parasites as well. Best to look at the symptoms under PARASITES…
~ The Cure Zone covered HS exceptionally well!
What is hidradenitis suppurativa?
Hidradenitis Suppurativa (HS), also known as ‘Acne Inversa’, is a physically, psychologically, and socially disabling disease affecting inverse areas of the body (those places where there is skin-to-skin contact – armpits, groin, breasts, etc.), and where apocrine glands and hair follicles are found. It is non-contagious and recurrent; typically manifesting as a progression from single boil-like, pus-filled abscesses, or hard sebaceous lumps, to painful, deep-seated, often inflamed clusters of lesions with chronic seepage (suppuration — hence the name) involving significant scarring.
Abscesses may be as large as baseballs in some people, are extremely painful to the touch and may persist for years with occasional to frequent periods of inflammation, culminating in drainage, often leaving open wounds that will not heal. These “flare-ups” are often triggered by stress, hormonal changes, or humid heat. Drainage of the lumps provides some relief from severe, often debilitating, pressure pain; however, pain occurs 24 hours a day, 7 days a week for HS sufferers during flare-ups, and is difficult to manage.
Persistent lesions may lead to the formation of sinus tracts, or tunnels connecting the abscesses under the skin. At this stage, complete healing is usually not possible, and progression of the disease in the area is inevitable. Occurrences of bacterial infections and cellulites (deep tissue inflammation) are likely at these sites.
Because of the drainage which may have a foul odor, fever and fatigue caused by acute inflammation and the physical restrictions caused by pain and skin deformation, people often cannot work, drive, exercise or even perform day-to-day tasks, and are ashamed to go out in public. HS sufferers may go through severe bouts of depression, avoid public and inter-personal contact, become sedentary and often overweight.
HS typically goes undiagnosed for years because patients are ashamed to speak with anyone. When they do see a doctor, the disease is frequently misdiagnosed. Only relatively few physicians are able to recognize it and even when they do, suggested treatments are often ineffective, temporary and sometimes even harmful. There is no known cure nor any consistently effective treatment; what works for one person may not work for another. In advanced, chronic cases, surgery is often the choice, but recurrences of HS are not uncommon.
The mechanisms of the disease are described in this article.
from The Cure Zone site…
Historically, HS has been considered a rare disorder, because it is difficult to accurately estimate the number of HS victims; they conceal their condition, even from friends and close relatives. Estimates, however, indicate at least 1 million – potentially up to 12 million – Hidradenitis Suppurativa sufferers in the United States alone!
What’s in a name…
HS was first described in 1839 and has since been called many names. We still cannot agree on what to call it. Germans prefer Akne Inversa, the French still like to use Verneuil’s, which we’ll admit, sounds much better than Hidradenitis Suppurativa (‘oozing inflamed sweat glands’). All are equally correct and equally wrong. All but names for symptoms of an underlying disease we don’t yet know.
…”correct” names for this disease:
Hidradenitis Suppurativa (HS)
alt: Hidradenitis Supportiva
Acne Inversa (AI)
Apocrine Acne
Acne conglobata
Verneuil’s disease
Velpeau’s disease
Fox-den disease
Pyodermia sinifica fistulans
Hidrosadénite Suppurée (fr)
Hidrosadenite Supurativa (es)
Idrosadenite suppurativa (it)
Maladie de Verneuil (fr)
Doença de Verneuil (pt)
Akne Inversa (de)
гнойного гидраденита (ru)
…has been diagnosed as, but is not:
~ Folliculitis
~ Acne
~ Boils
~ Cysts (sebaceous, inclusion and subcutaneous)
~ Furuncles
~ Carbuncles
~ Poor Hygiene
…is definitely not:
~ contagious
~ Herpes
~ Cancer
~ Allergies
~ Plague
…often happens in conjunction with:
~ PCOS / Insulin Resistance / Androgen Dysfunction
~ Crohns and other inflammatory auto-immune conditions
~ Anemia
~ Hyperhydrosis / hyperhidrosis
~ Depression
~ Acne Vulgaris / Cystic / Conglobata
~ Pilonidal cysts
Stages of the Disease
Hidradenitis typically develops slowly over time. Since there are no 100% successful treatments it will run its course. Development differs, however, from individual to individual. With some, the disease may stagnate and never develop past a mild stage, with others, it may escalate and become a debilitating disease. We do not know why.
This is how HS may progress:
~ Stage I: Solitary or multiple isolated abscess formation without scarring or sinus tracts;
~ Stage II: Recurrent abscesses, single or multiple widely separated lesions, with beginning sinus tract formation (“tunneling”) and cicatrisation (formation of scar tissue);
~ Stage III: Diffuse or broad involvement across a regional area with multiple interconnected sinus tracts, significant cicatrisation and persistent abscesses.
~ The Cure Zone … Hidradenitis Suppurativa (HS), also known as ‘Acne Inversa’, is a physically, psychologically, and socially disabling disease …
~ HS pictures…
~ by Victoria Stanell of Beautylish … Get the lowdown on “pimple geography” and learn why your zits can give you clues about other issues in your body.

~ Mayo Clinic … Hidradenitis suppurativa — Comprehensive overview covers causes, symptoms and treatments, which may include surgery. Includes picture.
Symptoms – Treatments and drugs – Hidradenitis suppurativa of the … – Causes
~ Medline Plus … Jul 17, 2012 – Hidradenitis suppurativa (HS) is a chronic disease of a type of sweat gland. … HS usually develops in your armpits, groin and anal area.
~ Genetics Home Reference … Hidradenitis suppurativa is a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin. The nodules are inflamed and painful… Wealth of info on topic, clinical trials, living with it, etc…
Hidradenitis Suppurativa Foundation, Inc. – A 501(c)(3) non-profit …
~ Hidradenitis Suppurativa Foundation, Inc. (HSF) … Mar 30, 2011 – Hidradenitis Suppurativa Foundation, Inc. Dedicated to improving the quality of life and quality of care for individuals and families affected by …
hidradenitis description
* While on search page then IMAGES on left side, they vary greatly!
hidradenitis description symptoms
hidradenitis description treatments
hidradenitis suppurativa
acne inversa
hidradenitides, suppurative
suppurative hidradenitides
suppurative hidradenitis

April 16, 2012

2004 PCOS Statistics

Posted in FACT tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , at 6:47 pm by PCOSLady

PCOS Lady: I found these statistics posted on a blog or site in 2004 or 2005… Makes you think how the numbers have increased and maybe decreased over the years… This was the reality of PCOS in 2004!
~ ~ ~
2004 Statistics

~ ~ ~
•~ 6-10% of all Females; ages 5+ years, are PCOS
•~ 30% of all PCOSers register as Insulin Resistant
•~ 50% of all PCOSers are overweight
•~ 40% (up to) of “Unexplained Infertility” patients are actually PCOS and don’t even know it!
•~ 30% of all PCOSers do not present cysts
•~ 20% of “Abnormal Glucose Tolerance” tests are PCOS
•~ 40% of “Abnormal Glucose Tolerance” develop diabetes or impaired glucose tolerance by age 40
•~ 20% of all infertility patients deal with ovulation problems
•~ 5% of all infertility patients treat their infertility
•~ 15% of all infertility patients treat their infertility in a mandated state for infertility coverage insurance
•~ 75% of all IVF patients deliver a singleton
•~ 20% of all IVF patients deliver twins
•~ 5% of all IVF patients deliver triplets
•~ 25% of normal pregnancies end in miscarriage
•~ 35-40% of PCOS pregnancies end in miscarriage. This is a 10-15% increase risk over ‘normal’ pregnancies.
I hope these statistics show you many things… 1st your doctors might be unaware of PCOS and its extremes… 2nd it effects your young girls… Bullying is an epidemic today, weight being a main cause… 3rd you may need to change your direction of testing, treatments, etc… 4th you may gained peace of mind in knowing more of what “it” might be or is… ETC… “IT” depends on YOU since PCOS effects every woman differently… Treatment varies for each woman too!
I am a firm believer many relationships, marriages and abuse of various degrees would be decreased IF we all know about PCOS…
~ If a female gains 100lbs over a year or close to it, she may have PCOS… Many females fall in to depression or hurt themselves when the weight will not go away!
* Have them tested for PCOS, a thyroid disorder or another hormone imbalance… Might be something else…


November 17, 2008

Nov ’08 Research: Treatments, Causes, Risks

Posted in RESEARCH tagged , , , , , , , , , , , at 12:41 am by PCOSLady

New Studies Examine Treatments, Causes and Risks for
Women with PCOS

Toronto, Canada, June 21, 2000 – New research presented today on treatments, causes and risks
associated with Polycystic Ovary Syndrome(PCOS)
, a disease that effects between five and 10 percent of reproductive aged women, offers a glimmer of hope to the millions of women who suffer from the disease. The research was presented today in a panel at ENDO 2000, The Endocrine Society’s 82nd Annual Meeting, which is taking place in Toronto from June 21-24. The new studies examine several areas of PCOS, including a possible gene that triggers PCOS, new treatments for the disease, the relationship between diet and PCOS and the risk of heart disease in women with PCOS….
Two of the studies that were presented examined new treatments for women with PCOS. One study found that women with PCOS who reduced their dietary fat might improve some of their reproductive parameters. Another study of adolescent girls with PCOS found that treatment with metformin, a medicine that decreases the body’s requirement for insulin, improves irregular or absent periods, a symptom of PCOS in young girls; lessens body hair and acne; and promotes weight loss…. “We have shown that metformin, which is typically a diabetes treatment, is effective in treating young women with PCOS,” said Dr. Ken Lee Jones, an endocrinologist at the University of California, San Diego who presented the research on metformin. “The new information that is presented today will help improve the quality of life for the women throughout the world who suffer from this disease.” … Dr. Walter Futterweit and Dr. Yaron Tomer,
endocrinologists at Mount Sinai Medical Center in New York, presented a study that found an association between a marker near the insulin receptor gene and PCOS. Previous research has found that PCOS is hereditary. The new research discovered evidence that the insulin receptor gene, or a nearby gene, may cause the tendency for women to inherit PCOS…. “This type of research will ultimately lead to better diagnosis and treatment for women with PCOS,” said Dr. Tomer….
Additionally, the research suggests that the inheritance of PCOS is caused by subtle changes in the insulin receptor gene, which may alter its function in the ovaries…. “We hope that these findings will enable us to better understand the mechanisms leading to PCOS,” said Dr. Futterweit…. Two of the other studies examined risk factors for women with PCOS, including insulin resistance and heart disease. One
study, which was presented by Dr. David Ehrmann, an endocrinologist at the University of Chicago, found that women with PCOS function near their maximum ability to secrete insulin in response to glucose. According to this new research, any further reductions in insulin sensitivity would be met with inadequate compensation in insulin secretion…. Dr. Rose Christian, a clinical research fellow
at the Mayo Clinic, reported on additional research that points to an increased risk of coronary heart disease for women with PCOS. Researchers found that coronary artery calcium, a marker for atherosclerosis, is more common and extensive in women with PCOS than in ovulatory women of similar age,
weight and risk factors…. “Our research showed that women with PCOS are as likely to develop coronary calcium as men of the same age,” said Dr. Christian. “Normally, coronary calcium and heart disease are three to four times more common in young men than in women of the same age.” … “PCOS is a common yet, silent disease that affects thousands of women,” said Dr. Lisa Fish, an endocrinologist at Park
Nicollett Medical Center in Minneapolis, Minnesota. “These studies provide new options to women with PCOS in treating their illness and also offer new information on risks that are associated with the it, such as heart disease. In addition, this research looks into the genes that may cause PCOS and its relationship to diabetes.” … Based in Bethesda, Maryland, The Endocrine Society consists of over 9,000 scientists and physicians in more than 80 countries. Founded in 1916, The Endocrine Society is the world’s oldest, largest, and most active organization devoted to research on hormones, and the clinical practice of endocrinology. Together, these physicians, scientists, educators, nurses, and students who
make up the organization’s membership, represent all basic, applied, and clinical interests in endocrinology. To learn more about The Endocrine Society, and thefield of endocrinology, visit our web site at…. New Directions in the Treatment of Polycystic Ovarian Syndrome by Ellen
Friedman Bender … Polycystic Ovarian Syndrome (PCOS) is a hormonal disorder affecting between 5 percent and 10 percent of women of reproductive age. Although many people correctly associate PCOS with impaired fertility
– chronic anovulation and hyperandrogenism (elevated male hormones) are two of its cardinal symptoms, it is more than an infertility disorder. Increasingly, PCOS is being recognized as a major women’s health problem because of the havoc it wreaks on the endocrine system. Many women with PCOS suffer from endocrine abnormalities including insulin resistance which affects the bodies ability to metabolize
sugar and fat….Significantly, according to a research study, premenopausal women who have the disorder are seven times more likely to suffer from adult onset diabetes than women without PCOS. In addition, over time, many women with PCOS develop elevated levels of cholesterol and triglycerides so that here is a greater risk of heart attack and stroke for women in their forties and fifties. Moreover, because of their irregular menstrual cycles, women with PCOS are at greater risk for endometrial cancer. Women with PCOS also frequently encounter self- esteem and body-image issues arising from other frequent symptoms of the disorder including hirsutism (excess facial and body hair),obesity, acne and male-pattern baldness… Traditionally, treatment for PCOS has focused on individual symptoms instead of the syndrome as a whole. Thus, a woman with PCOS who was trying to get pregnant might be given fertility drugs such as clomid
or pergonal. A woman in her twenties might be given oral contraceptives to regulate her menstrual cycle or provera to periodically shed the lining of her uterus. Another woman might be given spironolactone to inhibit hair growth. But recent research suggests that there may be lifestyle changes and medications that by attacking the insulin resistance, actually treat the syndrome as a whole…. At the very least,
some doctors recommend that their PCOS patients follow a carbohydrate-restricted diet and increase their exercise level. But the cutting edge research in PCOS is in the area of insulin sensitizing drugs. Recent studies have found that insulin sensitizing drugs given to type 2 diabetics, such as metformin, may also benefit women with PCOS. In one study, recently reported in the New England Journal of Medicine, an insulin sensitizing drug called INS-1 not only induced ovulation in 86% of the PCOS patients in the study,
it also reduced their triglyceride and blood pressure levels, lowering their risk for cardiovascular disease. At the moment, however, none of these insulin sensitizing agents are FDA approved for the treatment of PCOS and some of them have unpleasant side effects…. Ellen Friedman Bender co-chaired
the American Infertility Association’s recent conference on PCOS, “Understanding Polycystic Ovarian Syndrome: A Reproductive and Metabolic Disorder.” A version of this article appeared in the November 1999 issue of the Women’s O.W.N. of NYU Medical Center newsletter….
Treatment Options For PCOS
This information is provided for informational purposes only and is in no way meant to replace advice from a qualified medical professional…. Until recently, only the symptoms of PCOS – hirsutism, acne, infertility – could be treated. In the past few years, however, there has been a great deal of research pointing to excess production of insulin and resulting insulin resistance as the root of the problem….
Treatment With Insulin-Sensitizing Medications – The Newest Option A number of recent studies have shown
that treating women with PCOS with insulin-lowering medications such as metformin (also known as
Glucophage), Avandia (rosiglitazone) and Actos (pioglitazone), used to treat adult-onset diabetes,
can not only reduce the risks of heart disease and diabetes in women with PCOS by treating the underlying
problems with insulin production and usage, but also relieve many of the bothersome symptoms and even
make weight loss possible.1, 2
(Please note that these are not weight-loss drugs; women whose weight problems stemmed from insulin resistance may lose weight when the problem is corrected.)
These drugs do not lower blood sugar and so are generally safe even for those with hypoglycemia3, but there may be side effects. Metformin often causes diarrhea and/or nausea, especially for the first few weeks and when the dosage is increased. This is most problematic if it’s taken without food; these problems may be minimized by taking it halfway through a meal. A rare side effect is lactic acidosis, which may be fatal if not detected. Rezulin (troglitazone) was also used for this purpose until recently, but has been taken off the market after reports of liver abnormalities and even a handful of
deaths in some people who were taking it. Avandia and Actos are chemically related to Rezulin, but the effective dosages are far lower (4-8 mg/day of Avandia or 45 mg/day of Actos vs. 200-400 mg/day of Rezulin), making liver complications less likely. In clinical trials involving over 4500 patients, there have been no reports of Avandia-related liver toxicity or related problems4, 5; there have also been no reports of such complications from Actos4, 6 Even so, the FDA has recommended that patients who already have elevated liver enzyme levels be monitored regularly. Some people who take Avandia or Actos experience
a slight weight gain. (This hasn’t been my experience, though – I’ve actually lost several pounds in the last few months.) It is important to be aware that all of these medications are currently only approved by the FDA (in the US – I’m not entirely sure of their approval status in other countries) for the treatment of diabetes. There is a lot of convincing research showing that most if not all cases of PCOS can be improved by treating insulin resistance, and these drugs treat diabetes by treating insulin resistance. So, they’re likely to be helpful to many women with PCOS, and doctors are allowed to prescribe an approved drug for any purpose they wish, but some (especially those who aren’t up to date on the new research) may not be willing to do this. I’m working on writing up some information about d-chiro-inositol, the first medication being studied specifically to treat PCOS-related insulin resistance, but I want to do more research before I post anything here. In the meantime, check out Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome. This is an abstract of an article that appeared last year in the New England Journal of Medicine summarizing the findings of a study of this drug in women with PCOS….
Birth Control Pills
Birth control pills treat a few of the symptoms of PCOS. They usually bring on a period each month (though some women with PCOS do not have regular periods even while taking birth control pills) which is important for women who do not have regular cycles because lack of menstruation puts a woman at higher risk for endometrial cancer. Some women find that hair problems either lessen or stop getting worse while on the pill, particularly with Diane-35 or Dianette (which contains cyproterone acetate, an anti-androgen), which is available in some countries in Europe and also in Ausralia and New Zealand but has not been approved in the United States. Acne may improve as well. Weight gain is highly variable –
for some women weight gain may stabilize while on the pill; for others it may get worse. Changing brands may help if you find yourself gaining weight or having other unpleasant side effects. The triphasic birth control pills, such as Ortho Tri-Cyclen, may be problematic in that the estrogen dose they provide in the early part of the cycle may be too low to prevent women with PCOS from developing follicles, possibly resulting in a greater number of cysts on the ovaries.1 …
Treating Hirsutism
Hirsutism can an extremely difficult and emotional issue in a society where women are expected to be smooth and hairless. Shaving, plucking, waxing, electrolysis and laser hair removal treatments may work in many cases but can be, depending on the method, time-consuming, messy, painful and/or very
expensive. Spironolactone (brand name Aldactone), if taken over a period of time, will stop new hair growth in many women with hirsutism and may possibly decrease existing growth for some. In countries where Diane-35 has been approved, it may be prescribed help with hair problems….
Provera or other forms of synthetic progesterone are often prescribed to women experiencing amenhorrea
(lack of periods). It’s common for a Provera-induced period to be more heavy or painful than usual, but it’s important that something be done to cause regular menstruation because prolonged amenhorrea may
increase a woman’s risk for endometrial cancer. This doesn’t mean that if you haven’t had a period
for a very long time that you are destined to get cancer, but it does introduce a higher than usual risk. Some women have had success using progesterone cream as an alternative to Provera….
1. Kidson, Warren. Polycystic ovary syndrome: a new direction in treatment. MJA 1998; 169: 537-540.
2. Hopkinson, Zoe E. C. et al. Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology, BMJ 1998;317:329-332
3. Perloe, Mark. Polycystic Ovarian Syndrome: Treatment With Insulin-Lowering Medications.
4. Fonseca, Vivian A. Overcoming Insulin Resistance and Preventing Cardiovascular Disease in Diabetes: The Contributions of the Thiazolidinediones.
5. Avandia Shows Promising Results in Combination Therapy
6. Actos Approved By FDA For Type II Diabetes
April 28, 1999
New Drug May Help Women With Infertility Syndrome An investigational drug that helps insulin to function more efficiently appears to combat infertility in women with polycystic ovary syndrome (PCOS), the most common cause of female infertility, according to a research team funded in part by the National Institute
of Child Health and Human Development (NICHD). The drug, D-chiro- inositol, occurs naturally in fruits and vegetables and appears to have no side effects in the comparatively small number of PCOS
patients who took part in this preliminary trial….
The study, conducted by researchers at Virginia Commonwealth University (VCU) in Richmond, appears in the April 29 issue of The New England Journal of Medicine….
“These early results show a lot of promise,” said Dr. Donna Vogel, Associate Chief for Clinical Research in NICHD’s Reproductive Sciences Branch and NICHD program officer for the study. “Dr. Nestler and his
colleagues have shown that a substance naturally produced by the body to assist in insulin action promotes ovulation in the majority of PCOS patients who take it.” …
PCOS affects from 5 to 10 percent of American women of reproductive age (as many as 5 million in all), explained the study’s principal investigator, John E. Nestler, M.D., chairman of endocrinology at
VCU’s Medical College of Virginia. The ovaries of women with PCOS appear to be filled with numerous small cysts. The cyst-like appearance results from an accumulation of immature ovarian follicles, the bubble-like structures which, upon maturation, rupture and give rise to the egg cell….
The features of PCOS may include failure to ovulate or menstruate, abnormally high levels of insulin, obesity, high blood pressure, hardening of the arteries, and high triglyceride levels. (Triglycerides are fatty substances used for energy storage, and high triglyceride levels may increase the risk for coronary artery disease.) PCOS patients also have high levels of the male hormone testosterone, which may cause them to grow excess facial or body hair….
* “PCOS is not just a reproductive disorder; it’s a major health concern for women who are affected,” Dr. Nestler said. “This is a promising new drug because not only does it dramatically improve ovulation, it improves a woman’s overall health.” …
Dr. Nestler added that, traditionally, physicians have been able to treat only the symptoms of PCOS, and not eliminate its cause. For example, antiandrogens were prescribed to block the action of testosterone and reduce excessive hair growth. Birth control pills were used to regulate the menstrual cycle, and when the women sought to have children, they were treated with fertility drugs–either alone or in combination with in vitro fertililzation….
Roughly two years ago, however, Dr. Nestler and his colleagues were successful in reducing the PCOS symptoms of a group patients by treating them with the drug metformin, used to treat insulin resistance in patients with adult onset (type II) diabetes. (Insulin resistance is the failure of cells to respond to insulin properly). Metformin increases the body’s sensitivity to insulin and allows the body to use insulin more efficiently. Troglitazone, another insulin- sensitizing agent, has similar effects in PCOS patients. * …
Although both drugs do restore ovulation, both have a number of side effects. Metformin, for example, may cause diarrhea, nausea, and loss of appetite, and Troglitazone may be toxic to the liver….
The current findings strongly suggest that PCOS results from a failure to use insulin properly. Presumably, Dr. Nestler said, this failure causes insulin levels to rise. The high insulin levels, in turn, cause a variety of other effects, such as high blood pressure, hardening of the arteries, and high triglyceride levels. Insulin also appears to have an effect on the ovaries, causing them to produce high levels of testosterone and similar compounds, which halt egg maturation and interfere with the menstrual cycle….
In the current study, the researchers followed 44 obese women with PCOS; half received D-chiro-inositol, and half received a placebo. Of the 22 women who received the study drug, 86 percent ovulated, compared with only 27 percent of the women in the placebo group. Women who received D-chiro-inositol also saw improvements in insulin, blood sugar, blood pressure, testosterone and triglyceride levels. No side
effects were reported….
Dr. Nestler explained that the body uses D-chiro-inositol to manufacture the D-chiro-inositol mediator, which allows the cell toprocess glucose after insulin binds to the cell’s surface. According
to Dr. Nestler, the research offers insight into the possible cause of insulin resistance in women with PCOS, which previously had been unknown. A PCOS patient’s insulin resistance could be due, in part, to
a D-chiro-inositol deficiency….
NICHD is currently funding a trial of D-chiro-inositol in a large number of patients to further ascertain its safety and effectiveness. The drug is also being tested in patients with type II diabetes.
The study drug is manufactured by INSMED Pharmaceuticals, Inc., which develops products to detect and treat insulin resistance. The research is funded by an NIH Small Business Innovation Research Grant. These
grants are given to independently owned and operated U.S. companies that have fewer than 500 employees….
Polycystic Ovarian Syndrome
New Thought on an Old Disease
Polycystic Ovarian Syndrome (PCOS) has been a subject of intense interest and research since it’s initial description by Drs. Stein and Levinthal in the 1930′s. However, it was not until the 1980′s that an
association between this syndrome and insulin resistance was discovered, and only in the last several years that the benefit of insulin sensitize therapy in treating this condition has become known. Hence, the recent flurry of articles appearing not only in scientific journals but also in the lay press….
Why all the fuss? Probably because virtually everyone has a friend, relative or acquaintance who is affected with this disease. It is seen in 5-9% of reproductive age women, making it arguably the most common endocrine abnormality in this age group….
In spite of decades of research and volumes of material written on PCOS, there is not a universally agreed upon definition. The reasons for this is that the condition is a syndrome rather than a single
specific disease intensity. In other words, there are many discreet abnormalities, which may cause women to develop this syndrome, and each has certain unique features. However, although most of the “classic” signs or symptoms of PCOS are present in little more than half of women with this disease, irregular cycles with absent of infrequent ovulation is a prerequisite for labeling a patient with this diagnosis. Hair growth, acne, obesity, and the various hormonal and biochemical abnormalities associated with this condition are usually absent in at least a third of patients diagnosed with this condition….
Traditional therapies for Polycystic Ovarian Syndrome include bilateral ovarian wedge resection (now largely replaced by medical therapy or laparoscopic ovarian diathermy) contraception if patient does not wish to conceive, and clomiphene citrate if the patient is desirous of conception….
For patients who desire cycle control or relief from acne or hirsutism, oral contraceptives are the first line of management. Clomiphene citrate, which is an antiestrogen, can induce ovulation in PCOS patients by altering the natural secretion of ovulation enhancing hormones. However, only 60-80% of women with Polycystic Ovarian Syndrome will achieve regular spontaneous ovulation with this drug, and only about half of that number will ultimately conceive. The reason for this discrepancy between ovulation and pregnancy rates is not fully understood….
More recently, the role of insulin resistance in this condition has become better understood. In some individuals, insulin resistance is probably responsible for the development of PCOS. In others, it is
merely an association, linked either to obesity or genetic factors. There is a tremendous amount of research presently being conducted in this arena….
Of most significance to our patients with this condition, the role of insulin sensitizer therapy has become well known. There are three such medicines in used today, the common names of which are Actos, Avandia, and Glucophage. These medications allow the cells to respond more normally to the body’s insulin secretion which leads to a decrease in insulin production by the pancreas. The resulting decline in insulin levels affect a number of other pathways, ultimately improving a woman’s overall hormone balance and helping her to achieve ovulation more readily. In some women, insulin sensitizer therapy alone will
allow women with PCOS to ovulate and conceive. In others, medicines such as clomiphene citrate are still necessary. However, we now can help such women to ovulate with lower doses of clomiphene, and some
women who could not previously ovulate even with high and prolonged doses of Clomiphene can now conceive without having to resort to expensive injectable medications. Therefore, the extreme usefulness of
these medications in the treatment of this condition have become recognized as the first major medical advance in many years….
Not all women with PCOS have insulin resistance, and many who do have only a mild problem, which would probably not benefit from use of insulin sensitizer therapy. Often, these women may achieve similar or
better results using other methods such as weight loss and exercise. Adjunctive medications such as Tamoxifen or Decadron, or injectable menotropins may also be used with excellent results. Finally, ovarian
diathermy, in which the ovaries are treated with electrical energy during an outpatient laparoscopic procedure, produces excellent ovulation and pregnancy rates. It is beyond the scope of this article
to delineate the situations which would favor one treatment modality over another….
We have also become increasingly aware that there are sufficient long-term complications of insulin resistance and polycystic ovarian syndrome. During pregnancy, these patients display a higher incidence
of gestational diabetes, a potentially serious condition for the mother and fetus. Further on down the road it appears that women with PCOS are at significantly increased risk for hypertension, Type II
diabetes, and cardiovascular disease. There is currently much interest and research in this area, but as yet little information on how these potential complications are best avoided….
If you have or think you may have polycystic ovarian syndrome or insulin resistance, see your physician, or your infertility specialist for testing. Further details may be found on our web site, or through
national organizations such as Resolve or American Society for Reproductive Medicine…..
Future Research
The role of insulin sensitizers in the long-term treatment of PCOS is still relatively new and hotly debated. More research is being conducted to determine the safety and efficacy of these treatments

It has also been found that PCOS is highly genetic. By studying families where PCOS is seen in several women, studies will hopefully be able to identify the gene(s) contributing to this disease. Dr.
Andrea Dunaif, Chief of the Division of Endocrinology, Metabolism, and Molecular Medicine at Northwestern University Medical School and a member of the Advisory Board for the Polycystic Ovary Syndrome Association, is the Principal Investigator of an ongoing National Institutes of Health-funded study examining the genetics of PCOS. She is recruiting women with PCOS (diagnosed or undiagnosed) and their
family members to study the genetics of this syndrome….


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