September 25, 2013

Endocrine System

Posted in DIABETES, ENDOCTRINE DISORDER tagged , , , , , , , , , , , , , at 8:51 pm by PCOSLady

http://www.endocrineweb.com/conditions

About the Endocrine System
Endocrine Glands and Hormones

The Endocrine System Essentials

The endocrine system is made up of a network of glands.
These glands secrete hormones to regulate many bodily functions, including growth and metabolism.
Endocrine diseases are common and usually occur when glands produce an incorrect amount of hormones.

The endocrine system helps control the following processes and systems:

~ Growth and development
~ Homeostasis (the internal balance of body systems)
~ Metabolism (body energy levels)
~ Reproduction
~ Response to stimuli (stress and/or injury)

The Endocrine Network
The endocrine system completes these tasks through its network of glands, which are small but highly important organs that produce, store, and secrete hormones.

The glands of the endocrine system are:
~ Hypothalamus
~ Pineal Gland
~ Pituitary Gland
~ Thyroid
~ Parathyroid
~ Thymus
~ Adrenal
~ Pancreas
~ Ovaries
~ Testes

These glands produce different types of hormones that evoke a specific response in other cells, tissues, and/or organs located throughout the body. The hormones reach these faraway targets using the blood stream. Like the nervous system, the endocrine system is one of your body’s main communicators. But instead of using nerves to transmit information, the endocrine system uses blood vessels to deliver hormones to cells.

All Endocrine Disorders
~ Acromegaly ~ Cushing’s Syndrome ~ Goiters ~ Addison’s Disease ~ De Quervain’s Thyroiditis ~ Graves’ Disease ~ Adrenal Cancer ~ Diabetes ~ Growth Disorders ~ Adrenal Disorders ~ Follicular Thyroid Cancer ~ Growth Hormone Deficiency ~ Anaplastic Thyroid Cancer ~ Gestational Diabetes ~ Hashimoto’s Thyroiditis ~ Hurthle Cell Thyroid Cancer ~ Hypoparathyroidism ~ MEN 2B ~ Hyperglycemia ~ Hypothyroidism ~ Menopause ~ Hyperparathyroidism ~ Medullary Thyroid Cancer ~ Obesity ~ Hyperthyroidism ~ MEN 1 ~ Osteoporosis ~ Hypoglycemia ~ MEN 2A ~ Papillary Thyroid Cancer ~ Parathyroid Diseases ~ Reproduction ~ Thyroiditis ~ Pheochromocytoma ~ Silent Thyroiditis ~ Turner Syndrome ~ Pituitary Disorders ~ Thyroid Cancer ~ Type 1 Diabetes ~ Pituitary Tumors ~ Thyroid Diseases ~ Type 2 Diabetes ~ Pre-diabetes ~ Thyroid Nodules

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April 4, 2013

ADH1 to Methanol to Formaldehyde

Posted in ASPARTAME tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , at 10:57 pm by PCOSLady

PCOS Lady:
Diabetics and most people are having their ADH1 levels checked yearly… This post explains what the ADH1 actually is… This is scary and may scare you straight! I hope you think twice about smoking and eating or drinking anything with aspartame in it…
~ “YOU” are choosing the rate you will die… Be it fast or slow…
~ Knowing all this, ask; How much does your health care professional care about you?
~
ADH1 to Methanol to Formaldehyde
~
http://rmforall.blogspot.com/2013/03/table-52-is-key-chart-adh1-enzyme-at.html
~
Table 5.2 is the key chart — ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21
~
Table 5.2 is the key chart — ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21
~
http://rmforall.blogspot.com/2013/03/table-52-is-key-chart-adh1-enzyme-at.html
~
[ See also:,
http://articles.mercola.com/sites/articles/archive/2013/03/13/unlabeled-aspartame-use.aspx#
2013.03.13 292,095 visits in a week ]
~
[ welcome to a scientific bouquet — some tasty dishes are presented twice… ]
~
A liter of diet drink gives the same methanol (wood alcohol) as the smoke from a pack of cigarettes, 60 mg — methanol has a half-life in the human bloodstream of 3 hours, showing that its elimination is slow, while it reaches every part of the body and the fetus every minute.
~
Methanol is actually less toxic than ethanol, except when it goes easily into cells that also happen to have high levels of free floating ADH1 enzyme, in 19 specific human tissues, including inner walls of blood vessels in the brain and eye, as well as in the rods and cones of the retina — the methanol is made quickly into free floating formaldehyde inside these cells, where it naturally wrecks havoc, interfering with all biochemistry, just as in its well known uses for embalming and sterilizing medical tools.
~
The resulting stew of formaldehyde modified proteins activates the inflammation process of the immune system, producing complex evolving pussy lesions — brain in Alzheimer’s and multiple sclerosis, inner walls of blood vessels in atherosclerosis, skin fibroblasts in lupus, pancreas in diabetes 2, retina in macular degeneration, joint fibroblasts in rheumatoid arthritis
~
Methylation of DNA and RNA leads to cell dysfunction and death, many later cancers, and birth defects, spina bifida, autism, preterm birth, Fetal Alcohol Sydrome.
~
Two key ATP enzymes are impaired in mitochrondria, shutting down aerobic energy metabolism, leading to reduced metabolism and anaerobic buildup of lactic acid, resulting in acidosis.
~
http://www.whilesciencesleeps.com/audio-book/
~
Table 5.2: Target Organs of Methanol Toxicity (Bad ADH1 Sites)
pages 60-1 “While Science Sleeps” textbook 2012 January, 236 pages,
Chapter 5 “The Silent Battle That Turns Methanol into Disease” —
~
The key chart that summarizes how ADH1 enzyme in high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases:
~
http://www.whilesciencesleeps.com/references/
~
7 ADH1 references (listed below) for 16 tissue types (some tissues have several diseases) 218, 220, 221, 357, 503, 514, 563, 637, 638, 640;
~
18 target tissues for formaldehyde harm;
~
Over 20 specific modern novel “diseases of civilization”;
~
Each with huge growth in incidence in the last 35 years — 25 references;
~
U shaped curve (those who never drink ethanol get twice the harm for 6 of these diseases as those who drink once daily, since ethanol is a potent antidote that prevents ADH1 from making methanol into formaldehyde) — 8 references;
~
18 diseases from smoking cigarettes (a strong methanol source) — 24 references;
~
13 diseases from using aspartame — 22 references;
~
Monte didn’t have enough room on this 2-page figure to include the suite of 12 of the same symptoms and tissues from cases of often fatal chronic and acute methanol toxicity, page 133, with copious references.
~
This is a work in progress, highly incomplete, as this is an introductory update on the status of an breakthrough paradigm in toxicology, that presents multiple strong lines of evidence, allowing any intelligent layperson to come to their own decisions about methanol and resulting chronic formaldehyde toxicity diseases for specific high ADH1 sites, ranging from breast cancer to diabetes 2.
~
Table 5.2: target organs of methanol toxicity (bad ADH1 sites)
~
~ brain, vascular tissue, tau protein — Alzheimer’s myelin basic protein — multiple sclerosis
vascular lining — headache, seizures, glioblastoma cancer
~ eye, retina, ADH1 in rods and cones — macular degeneration
~ blood vessels, intima and media (inner walls), LDL low density lipoproteins — atherosclerosis
~ skin, fibroblasts — skin cancer, dermatitis, lupus (SLE systemic lupus erythematosus)
~ breast, epithelial (milk ducts) — adenocarcinoma
~ kidney, epithelial tubule — kidney cancer, poor function
~ bone, synovial fibroblast — rheumatoid arthritis
~ pancreas, islets of Langerhans — reduced insulin, diabetes 2
~ lung, fibroblasts — COPD chronic obstructive pulmonary disease, adenocarcinoma
~
Fetus, no ADH1 in placenta,
DNA methylation — terata (birth defects), autism
liver, lung, kidney harm — preterm delivery
~
Liver, highest ADH1 in body, many targets — hepatic cancer
~
“While Science Sleeps” textbook, 2012 January:
~
“Methanol travels easily to breast tissue and has been found in human milk. 219
~
The cells that produce milk within the breast, cells prone to develop
the most common of breast cancers, adenocarcinoma 358, contain high
levels of ADH1 enzyme, 358 allowing methanol’s conversion to
formaldehyde [ inside the cells as free floating acidic hydrated
formaldehyde, highly reactive on both sides of molecule ].
~
Mammary epithelial cells have no way to protect themselves from
formaldehyde 216 — no means to render it harmless.
~
They, unlike other breast tissue, contain no aldehyde dehydrogenase
enzyme (ADH 3) that could transform formaldehyde into the
non-carcinogenic formic acid. 216
~
Of particular interest are recent findings implicating ADH as playing
a pivotal role in the formation of breast cancer, documenting a
greater incidence of the disease in women with higher levels of ADH1
activity in their breasts. 357″
~
http://www.whilesciencesleeps.com/pdf/219.pdf
Labreche F, Goldberg M.
Exposure to Organic Solvents and Breast Cancer in Women: A Hypothesis.
American Journal of Industrial Medicine 1997;32:1-14.
~
http://www.whilesciencesleeps.com/pdf/358.pdf
Triano E, Slusher L, Atkins T, Beneski J, Gestl S.
Class I Alcohol Dehydrogenase Is Highly Expressed in Normal Human
Mammary Epithelium but not in Invasive Breast Cancer
: Implications for
Breast Carcinogenesis. Cancer Research Arch 2003;63:3092-100.
~
http://www.whilesciencesleeps.com/pdf/216.pdf
Crabb D, Matsumoto M, Chang D, You M.
Overview of the role of alcohol dehydrogenase and aldehyde
dehydrogenase and their variants in the genesis of alcohol-related
pathology
. Proceedings of the Nutrition Society 2004;63:49-63.
~
http://www.whilesciencesleeps.com/pdf/357.pdf
Coutelle C.
Risk Factors in Alcohol Associated Breast Cancer: Alcohol
Dehydrogenase Polymorphism and Estrogens
. International Journal of Oncology 2004;25:1127-32.
~
#6 diabetes 2 risk high for 2 cans aspartame diet drink weekly 14
years 66K women study
, Guy Fagherazzi et al AJCN 2013 Jan — methanol
(cigarettes, aspartame) formed into formaldehyde inside cells in
pancreas by ADH1 enzyme, WC Monte paradigm: Rich Murray 2013.02.13
http://rmforall.blogspot.com/2013/02/6-diabetes-2-risk-high-for-2-cans.html
~
The WC Monte January 2012 text is available at Amazon.com, “While
Science Sleeps”, low cost ebook, backed by his online archive of 745
free full text medical research references at WhileScienceSleeps.com ,
while two full chapters are free: Chapter 9, “Multiple Sclerosis” and
12, “Autism and Other Birth Defects.”
~
ADH1 is “unusually highly concentrated” in the million tiny “isles
of Langerhans” in the pancreas, where the beta cells make insulin —
cigarette use correlates with diabetes 2 risk, with a doubling of risk
for smoking over a pack daily.
[ page 172, “While Science Sleeps”, 2012 January, Prof. Woodrow C.
Monte, Food Science and Nutrition, Arizona State University, retired
2004 ]
~
WhileScienceSleeps.com includes free online archive of 745 full
text medical research references:
~
http://www.whilesciencesleeps.com/references/
~
http://www.whilesciencesleeps.com/pdf/637.pdf
Bühler R., Pestalozzi D., Hess M., Von Wartburg JP.
Immunohistochemical localization of alcohol dehydrogenase in human
kidney, endocrine organs and brain
.
Pharmacol Biochem Behav. 1983;
18 Suppl 1:55-9 1983;18(Suppl 1):55-9.
~
http://www.whilesciencesleeps.com/pdf/648.pdf
Willi C., Bodenmann P., Ghali WA., Faris PD., Cornuz J.
Active smoking and the risk of type 2 diabetes: a systematic review
and meta-analysis
.
JAMA 2007;298(22):2654-64.
~
http://www.whilesciencesleeps.com/pdf/283.pdf
Wei M, Gibbons L, Mitchell T, Kampert J, Blair S.
Alcohol intake and incidence of type 2 diabetes in men.
Diabetes Care 2000;23(1):16-21. Ming Wei mwei@cooperinst.org ]
~
Many of these diseases, including diabetes 2, are twice as harmful for
those who never drink ethanol, compared to those who have just one
standard drink a day, due to the inhibition by ethanol of formation of
formaldehyde from methanol by ADH1.
~
Many people are protected by methanol in their blood from fermentation by bacteria in the GI tract.
~
High levels of ADH1:
~ liver, kidney, lung;
~ intima and media (inner walls) of blood vessels, notably base of brain and retina;
~ rods and cones in retina;
~ purkinje cells of vermis in cerebellum;
~ islets of Langerhans in pancreas;
~ fibroblasts in skin, bone marrow, synovial tissues in joints;
~ milk ducts of breast;
~
Men have several times more ADH1 in their GI tract than women, so less methanol gets into the blood to attack other tissues, so now four times as many women get multiple sclerosis as men.
~
Sources of methanol (wood alcohol):
~ smoke from cigarettes, wood, peat;
~ aspartame, and chewing gums;
~ some dark wines and liquors;
~ fresh tomatoes, black currants;
~ unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers (including home preserves and jugs of apple cider by farming families);
~ jams jellies marmalades;
~ smoked fermented spoiled foods;
~ some fresh coffees;
~ approved food additive dimethyl dicarbonate;
~ vehicle fuels;
~
Medical chemical mortuary facilities, home and industry solvents, factories for processed wood and paper products — formaldehyde heated to 150 deg C releases methanol…
~
http://www.whilesciencesleeps.com/pdf/475.pdf
Eng L. Localizations of Spacific Brain Antigens.
In: Boese A, editor. Search for the Cause of Multiple Sclerosis and other Chronic Diseases of the Central Nervous System.
Basel: Verlag Chemie; 1980. p. 15-460.
~
Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system:
1. internat. symposion of Hertie Foundation in Frankfurt/Main, September 1979 / ed. by A.
Boese. — Weinheim, Deerfield Beach (Florida), Basel: Verlag Chemie, 1980.
ISBN 3-527-25875-2
~
Dr. Alfred Boese
GemeinnOtzige Hertie-Stiftung
Lyoner StraBe 15
D-6000 Frankfurt 71
~
http://www.whilesciencesleeps.com/pdf/218.pdf
Mori O, Haseba T, Kameyama K, Shimizu H.
Histological distribution of class III alcohol dehydrogenase in human brain.
Brain Research 2000;852:186-90.
mori-o@nms.ac.jp
~
http://www.whilesciencesleeps.com/pdf/220.pdf
Allili-Hassani A, Martinez S, Peralba J., et al.
Alcohol dehydrogenase of human and rat blood vessels:
Role in ethanol metabolism.
FEBS Letters 1997;405:26-30.
~
http://www.whilesciencesleeps.com/pdf/221.pdf
Buehler R, Hess M, Wartburg J.
Immunohistochemical Localization of Human Liver Alcohol Dehydrogenase in Liver Tissue, Cultured Fibroblasts, and HeLa Cells.
American Association of Pathologists 1982;108(1):89-99.
~
http://www.whilesciencesleeps.com/pdf/357.pdf
Coutelle C.
Risk Factors in Alcohol Associated Breast Cancer:
Alcohol Dehydrogenase Polymorphism and Estrogens. International Journal of Oncology 2004;25:1127-32.
Coutelle C, Höhn B, Benesova M, Oneta CM, Quattrochi P, Roth HJ, Schmidt-Gayk H, Schneeweiss A, Bastert G, Seitz HK. Department of Medicine
and Laboratory of Alcohol Research, Liver Disease and Nutrition,
Salem Medical Centre, Heidelberg, Germany.
~
http://www.whilesciencesleeps.com/pdf/503.pdf
Estonius M, Svensson S, Höög J.
Alcohol dehydrogenase in human tissues:
localisation of transcripts coding for five classes of the enzyme.
FEBS Lett. 1996;397:338-42.
~
http://www.whilesciencesleeps.com/pdf/514.pdf
Kinne R, Bräuer R, Stuhlmüller B, Palombo-Kinne E, Burmeste GR.
Macrophages in rheumatoid arthritis.
Arthritis Res 2000;2(3):189-202.
Raimund.W.Kinne@rz.uni-jena.de
[ no mention of ADH1 — the cause of RA is unknown… ]
~
SITES
~
GOOGLE:
aspartame
methanol
ethanol
formaldehyde
chronic formaldehyde toxicity diseases

April 16, 2012

IR – Insulin Resistance

Posted in IR - Insulin Resistance tagged , , , , , , , , , , , , , , , , at 6:40 am by PCOSLady

IR – Insulin Resistance
~
Insulin resistance is a condition in which the body produces insulin but does not use it properly. Insulin, a hormone made by the pancreas, helps the body use glucose for energy. Glucose is a form of sugar that is the body’s main source of energy.
~
When people are insulin resistant, their muscle, fat, and liver cells do not respond properly to insulin. As a result, their bodies need more insulin to help glucose enter cells. The pancreas tries to keep up with this increased demand for insulin by producing more. Eventually, the pancreas fails to keep up with the body’s need for insulin. Excess glucose builds up in the bloodstream, setting the stage for diabetes. Many people with insulin resistance have high levels of both glucose and insulin circulating in their blood at the same time.
From: http://diabetes.niddk.nih.gov/dm/pubs/insulinresistance/#what
~
IR effects so many of us by way of Diabetes, PCOS, and on & on involving your endocrine system plus more systems … 3 of 4 in the medical doctor pool are suggesting natural ways to manage your IR condition today… Ask your doctor!
~ Look in to the natural possibilities to manage your IR…
~
PCOS Lady:
~ I am against poisoning my body with drugs… A natural babe with most i say…
~ April 2012: I’m back on Glucophage XR 500mg/daily i must use to get rid of my IR fat i call it… Errrr! Gluc is like a “miracle” pill for me… The side effects are mostly pluses too…
~ I have tried losing the IR fat a few months now with no luck… My body started taking from my muscle mass! Clue- peeing like a race horse at times…
~ My Asian MD in California told me to use Glucophage XR as a maintenance pill… I may have to split the pill or take it every other day, etc… per him to find what works for me…
~
From: Insulite Laboratories
http://weight.insulitelabs.com/
~
Medical research has now identified insulin resistance as a serious condition that causes your cells to become insensitive to insulin. When people suffering from excess weight or obesity fail to address insulin resistance, the possibility of severe complications such as cardiovascular disease, high blood pressure and sexual dysfunction can dramatically accelerate.
~
The medical community is now beginning to understand how vital it is for our cells to receive the correct amounts of nutrients and minerals – such as alpha-lipoic acid, chromium, vitamin D and magnesium – in order to effectively process insulin and glucose.
~
Tests:
In order to process insulin and glucose properly you need to have these nutrients and mineral levels checked:
~ alpha-lipoic acid
~ chromium
~ vitamin D
~ Magnesium
~
Sites
~
IR+: http://www.pcos.insulitelabs.com/Insulite-Laboratories.php
~ Insulite Laboratories … IR, Metabolic Syndrome, PCOS, etc…
~
http://home.comcast.net/~creationsunltd/insulinresistance.htm
~ From: Pat Sonnenstuhl, RN, CNM, Nutrition Support … Extensive information on topics…
~
http://diabetes.niddk.nih.gov/dm/pubs/insulinresistance/
~ National Diabetes Information Clearinghouse …

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